Technique of preventive treatment of children with immunobiological disorders and children infected with drug-resistant strains of tuberculosis mycobacteria
Abstract
Purpose. To develop the optimized technique of the prevention of development of local tuberculosis in children infected with drug-resistant strains of tuberculosis mycobacteria (TMB).
Materials and methods. Object of research were statistical accounting data for 2002-2004 of the Republican antitubercular clinic, children at the age of 2 to 14 years who were divided into 2 groups: 1-st (basic): 80 children, received ХП (preventive treatment) in the strengthened condition. They were divided into 2 subgroups: 1-st A - 40 children from contacts with patients allocating DR strains of TMB. 1-st B - 40 children from contacts with patients allocating TMB with medicinal sensitivity, 2-nd (control): 40 children who received chemoprophylaxis by a standard technique.
Results. The frequency of children’s infecting with DR strains of TMB and degree of risk of development of tuberculosis in the given category of children were determined. For the first time clinic laboratory displays and features of reaction of the immune system of children infected with DR strains of TMB were revealed. New data on uniformity of infringements of immunologic reactance in children, infected with DR strains of TMB and children suffering from drug-resistant tuberculosis was obtained. Application of preventive treatment in the strengthened condition in a complex with immunocorrector lycopid for the prevention of disease was proved. The scheme of differential diagnostics of infecting with drug-resistant and sensitive strains of TMB was developed. The symtomatology of immunobiologic infringements in children infected with DR strains of TMB was determined. The technique of its correction was developed.
Conclusion. The technique of preventive treatment appeared more effective in comparison with the standard scheme of chemoprophylaxis and as the result of it can be the decrease of tuberculoses sensitivity of all parameters, the essential increase of an annual gain of weight and body height parameters, the decrease in frequency of sharp respiratory infections, the normalization of parameters of the immune status and absence of tuberculosis morbidity.
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Review
For citations:
Luginova E.F. Technique of preventive treatment of children with immunobiological disorders and children infected with drug-resistant strains of tuberculosis mycobacteria. Yakut Medical Journal. 2007;(1):16-20. (In Russ.)
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