Morphological features of the НР- associated gastritises in the indigenous and non-indigenous children of the Republic Sakha (Yakutia)

Abstract

The purpose of research was to reveal morphological features of changes in a mucous membrane of the stomach at НР- associated gastritis in children and teenagers living in Republic Sakha (Yakutia).
Material and methods of research. 188 biopsy materials from the antral portion of the stomach in children in the age of from 7 till 17 years with a dyspepsia clinical picture were investigated by endoscopic and histilogic methods (with the use of morphometry), 69 girls and 119 boys from them. In structure of the surveyed indigenous children -131, non - indigenous - 75.
Results. Frequency of the НР - infection in the general structure of the surveyed children and teenagers in the age of 7-17 years has made 58,5 % (р=0,01). On a morphological picture, the prevailing form of gastritises was a chronic superficial gastritis. Chronic gastritises in children of 7-9 years were associated with the second and third degrees of the НР-infection, and in teenagers of 15-17 years with the first degree of the НРinfection and their absence.
The conclusion. At the adult population of Yakutia infection with the НР occurs mainly in the childhood and increases with the years, as the early childhood is the critical period on НР-infection. The chronic infection caused by Helicobacter pylori leads to multifocal or diffusive atrophic gastritis and gastric epithelium metaplasia.