Blood integrated indicator of oxidative stress in infants born to HIV-infected mothers
N. A. Kurashova,
A. G. Petrova,
A. S. Vanyarkina,
L. V. Rychkova,
M. A. Darenskaya,
E. V. Moskaleva,
L. I. Kolesnikova https://doi.org/10.25789/YMJ.2023.83.19
Abstract
A single-center cross-sectional study was conducted from March 2020 to January 2021 and included 142 neonates born with a gestational age of more than 37 0/7 weeks. The aim of the work was an individual assessment of the oxidative stress index (OSI) in newborns of HIV-infected mothers. Materials and methods: the state of the LPO–AOD system was assessed by determining the content of lipid peroxidation oxidation substrates with conjugated double bonds (DB), diene conjugates (DC), ketodienes and conjugated trienes (KD and CT), TBA-active products in the blood (TBA-AP), retinol, α-tocopherol, reduced (GSH) and oxidized glutathione (GSSG), superoxide dismutase (SOD) activity. OSI was used to evaluate differences in lipid peroxidation processes in HIV-exposed uninfected newborns. Results: The index of oxidative stress in the group of HIV-exposed uninfected newborns was detected 1.98 times higher compared to healthy newborns and was 2.5 and 1.26, respectively. The value of the oxidative stress coefficient indicates a significant imbalance in the LPO-AOP system reflecting the enhancement of the lipid peroxidation processes. An increase in the concentration of substrates and products of peroxidation leads to the destruction of lipids, and, consequently, to the degradation of the cell membrane complex. Conclusion: The integral oxidative stress index is recommended as a general indicator that characterizes the level of lipid peroxidation products and antioxidant protection factors in a particular group. Also, OSI is more sensitive indicator than separated components of the system, which objectively represents the LPO–AOD system malfunctioning, and provides the comprehensive view to the both lipid peroxidation processes and the level (effectiveness) of protective factors. To summarize, the results of the study point to the need to further investigations aimed to determination of prognostically significant markers in PVEN, which could be involved or could indicate the pathological processes both in the early neonatal period and in the later stages of infant development.
About the Authors
N. A. Kurashova
Scientific Сentre for Family Health and Human Reproduction Problems
Russian Federation
Russian Federation
KURASHOVA Nadezhda A. – Dr. Sci. (Biology), leading researcher, Laboratory of Pathophysiology
Irkutsk
A. G. Petrova
Scientific Сentre for Family Health and Human Reproduction Problems
Russian Federation
Russian Federation
PETROVA Alla G. – Dr. Sci. (Med.), Professor, chief researcher, Laboratory of Infectology and Immune Prophylaxis in Pediatrics
Irkutsk
A. S. Vanyarkina
Scientific Сentre for Family Health and Human Reproduction Problems
Russian Federation
Russian Federation
VANYARKINA Anastasia S. – Cand. Sci. (Med.), chief researcher, Laboratory of Infectology and Immune Prophylaxis in Pediatrics
Irkutsk
L. V. Rychkova
Scientific Сentre for Family Health and Human Reproduction Problems
Russian Federation
Russian Federation
RYCHKOVA Lubov V. – Dr. Sci. (Med.), Professor, Corresponding member of the Russian Academy of Sciences
Irkutsk
M. A. Darenskaya
Scientific Сentre for Family Health and Human Reproduction Problems
Russian Federation
Russian Federation
DARENSKAYA Marina A. – Dr. Sci. (Biology), chief researcher, Laboratory of Pathophysiology
Irkutsk
E. V. Moskaleva
Scientific Сentre for Family Health and Human Reproduction Problems
Russian Federation
Russian Federation
MOSKALEVA Ekaterina V. – Cand. Sci. (Med.), Researcher, Laboratory of Infectology and Immune Prophylaxis in Pediatric
Irkutsk
L. I. Kolesnikova
Scientific Сentre for Family Health and Human Reproduction Problems
Russian Federation
Russian Federation
KOLESNIKOVA Lubov I. – Dr. Sci. (Med.), Professor, Member of the Russian Academy of Sciences, Academic Director
Irkutsk
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Review
For citations:
Kurashova N.A., Petrova A.G., Vanyarkina A.S., Rychkova L.V., Darenskaya M.A., Moskaleva E.V., Kolesnikova L.I. Blood integrated indicator of oxidative stress in infants born to HIV-infected mothers. Yakut Medical Journal. 2023;(3):75-78. https://doi.org/10.25789/YMJ.2023.83.19
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