Distribution of genotype and allel rates in polymorphal locuses of cardiovascular pathology gene candidates in Yakut population and analysis of its associations with myocardial infarction
Abstract
Purpose. Determination of genotype and allel rates, analysis of associations of polymorphisms eNOS VNTR, AT1R 1166FA/ C, ACE I/D, ApoE Arg158Cys, Cys112Arg, ApoB Xbal and EcoRI for determining risk of myocardial infarction process in Yakut population.
Methods. Allel and genotype rates of polymorphal types of cardiovascular disease (CVD) gene-candidates in Yakut population were studied by a method of polymer chain reaction and RFLP; analysis of associations with risk of myocardial infarction process in men of Yakut nationality was conducted.
Results. In the Yakut population we detected associations with risk of myocardial infarction process in such polymorphal locuses of CVD gene canidates (P<0.05) as: AT1R 1166FA/C, ApoB Xbal and EcoRI , eNOS VNTR. Distinctions between polymorphal locuses ApoE Arg158Cys, Cys112Arg, ACE I/D of control group and patients were observed at a level of tendency.
Conclusion. Associations of polymorphisms AT1R 1166FA/C, ApoB Xbal with myocardial infarction were detected in the Yakut population. Allel eNOS*A of polymorphism eNOS VNTR is noted as a marker of MI high risk.
About the Authors
L. V. Grigorieva
ЯНЦ РАМН и Правительства РС(Я)
Russian Federation
Russian Federation
A. N. Romanova
ЯНЦ РАМН
Russian Federation
Russian Federation
E. S. Kylbanova
ЯНЦ РАМН
Russian Federation
Russian Federation
N. V. Makharova
ЯНЦ РАМН
Russian Federation
Russian Federation
L. V. Tarabukina
РБ №1-НЦМ
Russian Federation
Russian Federation
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Review
For citations:
Grigorieva L.V., Romanova A.N., Kylbanova E.S., Makharova N.V., Tarabukina L.V. Distribution of genotype and allel rates in polymorphal locuses of cardiovascular pathology gene candidates in Yakut population and analysis of its associations with myocardial infarction. Yakut Medical Journal. 2006;(2):16-19. (In Russ.)
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