Features of experimental animals adaptable reaction under the influence of low temperature
Abstract
Aim. An estimation of compensatory adaptive reactions of an organism with hypothermia. The experiment was held on rats.
Methods and materials. The experiment was conducted on 12 rats divided into two groups depending on time of an exposition on a cold. The control group consisted from 5 intact animals. The inЯuence of low temperature on an organism of experimental animals was estimated according to phagocyte activity of leukocytes, free-radical oxidation and antioxidant protection of an organism.
Conclusion. Animals, subjected to hypothermia in current of three hours, had more effective adaptation which was shown in reduction of neutrophils' phagocyte activity, by maintenance of balance between peroxide oxidation of lipids (POL) and antioxidant protection (AP). And rats, subjected to hypothermia in current of one hour, had failure in compensatory and adaptive reactions. It was shown in infringement of balance of POL-AP, oppressions of phagocyte activity and also non-speciюc reaction of an organism (NRO) "reactivation" in comparison with intact group of animals.
About the Authors
V. M. Nikolaev
ЯНЦ РАМН и Правительства РС(Я)
Russian Federation
Russian Federation
A. S. Golderova
ЯНЦ РАМН и Правительства РС(Я)
Russian Federation
Russian Federation
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Review
For citations:
Nikolaev V.M., Golderova A.S. Features of experimental animals adaptable reaction under the influence of low temperature. Yakut Medical Journal. 2006;(4):21-23. (In Russ.)
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