Association of the FTO gene polymorphism (rs9939609) with body mass index in the Yakut population
https://doi.org/10.25789/YMJ.2024.86.09
Abstract
The study is devoted to studying the relationship between the rs9939609 polymorphism of the FTO gene and body mass index (BMI) in the Yakut population. The sample consisted of 521 participants of Yakut nationality without diabetes mellitus and not registered with a dispensary, aged from 18 to 75 years, 222 women and 299 men. An analysis of the distribution of frequencies of occurrence of alleles and genotypes was carried out, as well as an analysis of BMI indicators in groups with different genotypes of the rs9939609 polymorphism of the FTO gene, during which similarities were found in the ratios of allele frequencies with populations of East and South Asia. Statistical analysis using the Kruskal-Wallis test with multiple analysis Dunn's test with Bonferroni correction and the odds ratio (OR) with the significance test with Yates' correction within the study showed a weak association of obesity with the risk allele A when comparing the group with normal BMI and the combined group of obesity + pre-obesity p = 0.043.
About the Authors
A. A. Bochurov
Federal State Budgetary Scientific Institution Yakut Science Centre of Complex Medical Problems
Russian Federation
Russian Federation
Bochurov Alexey Alekseevich – junior researcher of the Laboratory of Hereditary Pathology, Department of Molecular Genetics
N. I. Pavlova
Federal State Budgetary Scientific Institution Yakut Science Centre of Complex Medical Problems
Russian Federation
Russian Federation
Pavlova Nadezhda Ivanovna – PhD in Biology, leading researcher Head of the Laboratory of Hereditary Pathology, Department of Molecular Genetics
A. V. Krylov
Federal State Budgetary Scientific Institution Yakut Science Centre of Complex Medical Problems
Russian Federation
Russian Federation
Krylov Alexey Vasilievich – junior researcher of the Laboratory of Hereditary Pathology, Department of Molecular Genetics
S. K. Kononova
Federal State Budgetary Scientific Institution Yakut Science Centre of Complex Medical Problems
Russian Federation
Russian Federation
Kononova Sardana Kononovna – PhD in Biology, chief researcher, head of the Department of Molecular Genetics
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Review
For citations:
Bochurov A.A., Pavlova N.I., Krylov A.V., Kononova S.K. Association of the FTO gene polymorphism (rs9939609) with body mass index in the Yakut population. Yakut Medical Journal. 2024;(2):35-38. https://doi.org/10.25789/YMJ.2024.86.09
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