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Role of g-IFN in Viluisk encephalomyelitis pathogenesis

Abstract

The analysis of cytokine g-IFN participation in the immune response of the patient has revealed existence of three stages of immune reactivity in pathogenesis, defining Viluisk encephalomyelitis clinical forms.

About the Author

V. L. Osakovskij
ФГНУ «Институт здоровья»
Russian Federation


References

1. Danilova A.P. Diagnostics of Viluisk encephalomyelitis chronic forms / А.P Danilova, T.M. Sivtseva, M.N. Jakovleva // III International conference on a problem of Viluiskencephalomyelitis and neurodegenerative diseases of cerebrum in Yakutia.-Yakutsk, 2006. P.44-45 .

2. Molecular-cellular aspects of human pathology in the North. /Fedorov A.I. and et al. // Thes.rep. of Inter-regional scient.-practical conf., devoted to the 50th anniversary of the high medical school in Yakutia.-Yakutsk, 2007.-P. 36-37.

3. Interferon gamma and tumor necrosis factoralpha regulate amyloid-beta plaque deposition and beta-secretase expression in Swedish mutant APP transgenic mice /Yamamoto M [et all] //Am.J. Pathology, 2007,170(2): 680-92.

4. Gallucci S. Natural adjuvants: Endogenous activators of dendritic cells / S. Gallucci, M. Lolkema, P. Matzinger // Nature Medicine.- 1999.- V.5, issue 11.- P.1249-1255.

5. Innale immunity in multiple sclerosis: myeloid dendritic cell in secondary progressive multiple sclerosis are activated and drive a proinflammatory immune response/ A. Karni [et all] // J Immunol. - 2006. -Sep15; 177(6): 4196-4202.

6. Viluisk encephalomyelitis: intrathecal synthesis of oligoclonal IgG / A.J. Green [et all] //Journal of neurological sciences.-2003, № 212, р.69-73.

7. Weiner HL. The challenge of multiple sclerosis: how do we cure a chronic heterogeneous disease? /HL. Weiner// Ann. Neurol. - 2009. Mar; 65(3): 239-248.


Review

For citations:


Osakovskij V.L. Role of g-IFN in Viluisk encephalomyelitis pathogenesis. Yakut Medical Journal. 2010;(3):73-75. (In Russ.)

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ISSN 1813-1905 (Print)
ISSN 2312-1017 (Online)