Antigen-induced production of perforin in a population of cytotoxic (СD8) Т-lymphocytes
Abstract
11 patients infected with mycobacterium tuberculosis (MBT) within no more than 2 year term at absence of radiological attributes of local primary tuberculosis and 10 patients with for the first time revealed pulmonary tuberculosis were included into our research. During immunological research populational structure of peripheral blood lymphocytes and perforin production by peripheral blood mononuclears before antibacterial therapy were defined. At an induction by both PPD and ESAT-6 antigens percents of cytotoxic (CD8) Т– lymphocytes, producing perforin, were considerably higher in group of patients with active pulmonary tuberculosis, than in group of MBT infected patients. The received results testify to an opportunity of differentiation of a latent tubercular infection from active process at the analysis of antigen-induced population perforin producing cytotoxic Т– lymphocytes.
About the Authors
L. I. Mordovskaja
ГУ НПЦ «Фтизиатрия» МЗ РС (Я)
Russian Federation
Russian Federation
V. A. Aksenova
НИИ фтизиопульмонологии ММА им. И.М. Сеченова
Russian Federation
Russian Federation
M. A. Vladimirskij
НИИ фтизиопульмонологии ММА
Russian Federation
Russian Federation
T. I. Arefeva
Российский кардиологический научно-производственный центр РАМН
Russian Federation
Russian Federation
References
1. Human cytolytic and interferon-gammasecreting CD8+ T lymphocytes specific for Mycobacterium tuberculosis / Lalvani A. [et al.] // Proc. Natl. Acad. Sci. U. S. A. – 1998. – Vol. 95, №1. – P.270 – 275.
2. Recombinant early secreted antigen target 6 protein as a skin test antigen for the specific detection of Mycobacterium tuberculosis infection / Wu X. [et al.] // Clin. Exp. Immunol. – 2008. – Vol.152. – №1. – P. 81 – 87.
3. Tuberculosis associated with infliximab, a tumor necrosis factor-alphs neutralizing agent/ Keane J. [et al.] // N. Engl. J. Med. – 2001. – Vol. -345. – P. 1098 – 1104.
4. Woodworth J.S. Mycobacterium tuberculosis-specific CD8+ T cells require perforin to kill target cells and provide protection in vivo / Woodworth J. S., Wu Y., Behar S. M. J. // Immunol. – 2008. – Vol. 181, №12. – Р. 8595 – 8603.
Review
For citations:
Mordovskaja L.I., Aksenova V.A., Vladimirskij M.A., Arefeva T.I. Antigen-induced production of perforin in a population of cytotoxic (СD8) Т-lymphocytes. Yakut Medical Journal. 2010;(3):41-43. (In Russ.)
Views:
17
Email this article 