Role of genes еNOS, ACE and MTHFR polymorphism in gestosis development in the Yakut population
Abstract
Polymorphic variants of the genes responsible for functioning of factors of endothelial system: endothelial synthase of nitrogen oxide, angiotensin converting enzyme and methylenetetrahydrofolate reductase were under research. Authentic differences of alleles and genotypes on a locus - C691T of gene eNOS and I/D-polymorphism of gene ACE in the studied groups are revealed. It is possible to consider C-allele of a polymorphic variant - С691Т of gene eNOS and D-allele of gene ACE as component of hereditary predisposition to gestosis development in the Yakut population.
About the Authors
K. K. Pavlova
ЯНЦ КМП СО РАМН
Russian Federation
Russian Federation
E. A. Trifonova
НИИ МГ СО РАМН
Russian Federation
Russian Federation
L. V. Gotovtseva
ЯНЦ КМП СО РАМН
Russian Federation
Russian Federation
N. R. Maksimova
ЯНЦ КМП СО РАМН
Russian Federation
Russian Federation
A. N. Nogovitsyna
ЯНЦ КМП СО РАМН
Russian Federation
Russian Federation
V. A. Stepanov
НИИ МГ СО РАМН
Russian Federation
Russian Federation
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Review
For citations:
Pavlova K.K., Trifonova E.A., Gotovtseva L.V., Maksimova N.R., Nogovitsyna A.N., Stepanov V.A. Role of genes еNOS, ACE and MTHFR polymorphism in gestosis development in the Yakut population. Yakut Medical Journal. 2010;(3):28-31. (In Russ.)
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