Influence of fenazepam on heart rhythm in patients with myocardial infarction
Abstract
Efficiency and safety of application of fenazepam in complex therapy in 60 patients with IHD, acute myocardial infarction, complicated by rhythm disorders is studied. It is established that on a background of standard treatment with cardiotropic preparations with addition of fenazepam in a daily doze of 1 mg in patients with acute myocardial infarction as a whole statistically significant reduction of both over-ventricular and ventricular extrasystoles is marked. In patients of control group with acute myocardial infarction on a background of standard treatment reduction of geterotropic arrhythmias is marked, however unlike the basic group significant changes are not revealed.
About the Authors
L. S. Polikarpov
ГОУ ВПО КрасГМУ им. проф. Ф.В. Войно-Ясенецкого Минздравсоцразвития РФ;
НИИ медицинских проблем Севера СО РАМН
Russian Federation
Russian Federation
E. V. Derevjannyh
ГОУ ВПО КрасГМУ им. проф. Ф.В. Войно-Ясенецкого Минздравсоцразвития РФ
Russian Federation
Russian Federation
E. O. Karpuhina
ГОУ ВПО КрасГМУ им. проф. Ф.В. Войно-Ясенецкого Минздравсоцразвития РФ
Russian Federation
Russian Federation
E. A. Savchenko
ГОУ ВПО КрасГМУ им. проф. Ф.В. Войно-Ясенецкого Минздравсоцразвития РФ
Russian Federation
Russian Federation
A. G. Ivanov
ГОУ ВПО КрасГМУ им. проф. Ф.В. Войно-Ясенецкого Минздравсоцразвития РФ
Russian Federation
Russian Federation
R. A. Jaskevich
ГОУ ВПО КрасГМУ им. проф. Ф.В. Войно-Ясенецкого Минздравсоцразвития РФ;
НИИ медицинских проблем Севера СО РАМН;
Russian Federation
Russian Federation
References
1. Buldakova N.G. Psychopharmacotherapy in cardiology / N.G. Buldakova // Rus.med. J. - 2006. - V.14. – No.10. - P 8 - 13.
2. Burchinsky S.G. Ancsiolitics in a cardiological practice / S.G. Burchinsky // Здоров’я України -2008. - 11/1. - P. 30 - 31.
3. Meerson F.Z. Adaptation to stressful situations and physical activities / F.Z. Meerson., M.G. Pshennikova - М.: Medicine, 1988. - 256 p.
4. Meerson F.Z. Pathogenesis and the prevention of stressful and ischemic heart disorders // F.Z . Meerson - М.: Medicine, 1984. - 272 p.
5. Kryzhanovsky G. N. Changes of a heart rhythm activity at hyperactivation of anterior amygdalar nucleus / G.N. Kryzhanovsky, J.I. Pivovarov // Bull. Exper. Biology and medicine. - 1982. V.93. - №5. - P. 28 - 29.
6. The positive effect of adaptation to periodic hypoxia in conditions of a pressure chamber at the idiopathic arrhythmias / F.Z. Meerson [, et. al.] // Cardiology.-1989. - V.29. - №6.-P. 53 - 56.
7. The prevention of arrhythmias and heart fibrillation at acute ischemia and reperfusion by means of the factor causing accumulation of GABA in brain /F.Z. Meerson [, et al.] // Bull. Exper. Biology and medicine. - 1987. - V.27. - №5. - P. 87 - 89.
8. Zakusov V.V New evidences of GABA – ergic component in the mechanism of action of benzodiazepine tranquilizers / V.V. Zakusov, R.U. Ostrovskaja // Bull. Exper. Biology and medicine. - 1981. - V.91.-5. - P. 571 - 574.
9. GABA-A receptors: drug binding profile and distribution of receptors containing the, α2-subunit in situ / D. Marksitzer [et al.] // J. Receptor Res. - 1993. - Vol. 13. – P. 467 - 477.
10. Raj A. Benzodiazepines / A. Raj, D. Seehan // The American psychiatric publishing text-book of psychopharmacology. 3rd ed. Wash. (D.C.): Amer. Psychiat. publ. - 2004. - P. 371 - 391.
Review
For citations:
Polikarpov L.S., Derevjannyh E.V., Karpuhina E.O., Savchenko E.A., Ivanov A.G., Jaskevich R.A. Influence of fenazepam on heart rhythm in patients with myocardial infarction. Yakut Medical Journal. 2010;(3):22-24. (In Russ.)
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