Use of methods of neuronet modeling and the discriminantal analysis for estimation of the immune status condition in patients with acute nonlymphoblast leukemia
Abstract
The purpose of the present research was studying of a condition of cellular and humoral immunity links in patients with acute non-lymphoblast leukemia, using various statistical methods for estimation. It was revealed, that at a stage of attack and remission of acute non-lymphoblast leukemia the T-cellular immunodeficiency developed, at a stage of relapse - the combined immunodeficiency with lesion of Т-and В-systems of immunity. The exhaustion of the NK-cells content which promotes progressing of disease and development of relapse is the feature of acute non-lymphoblast leukemia. Neuronet modeling and the discriminantal analysis have revealed the most significant parameters of the system analysis change of which promote both to occurrence, and progressing of oncological disease.
About the Authors
V. T. Manchuk
НИИ медицинских проблем Севера СО РАМН
Russian Federation
Russian Federation
O. V. Smirnova
НИИ медицинских проблем Севера СО РАМН
Russian Federation
Russian Federation
References
1. Волкова М.А. Клиническая онкогематология / М.А. Волкова, – М.: Медицина, 2001.
2. Воробьев А.И. Руководство по гематологии. В 3 т. / А.И. Воробьев, – М.: Ньюдиамед, 2002. – Т. 1.
3. Земсков А.М. Дополнительные методы оценки иммунного статуса / А.М. Земсков, В.М. Земсков, – Клин. лаб. диагностика. – 1994. – № 3. – С. 34-35.
4. Ковалева Л.Г. Острые лейкозы / Л.Г. Ковалева, – М.: Медицина, 1990.
5. Natural killer cell receptors: new biology and insights into the graft-versus-leukemia effect /S.S. Faray [et al.] // Blood.- 2002.- №100.- р. 1935-1947.
6. Lanier L.L. Natural killer cell receptor signaling / L.L. Lanier // Current Opinion in Immunology.- 2003.- №15.- P. 308-314.
7. Lian R.H. Murine natural killer cell progenitors and their requirements for development /R.H. Lian, V. Kumar // Immunology.- 2002.- №14.- р. 453-460.
Review
For citations:
Manchuk V.T., Smirnova O.V. Use of methods of neuronet modeling and the discriminantal analysis for estimation of the immune status condition in patients with acute nonlymphoblast leukemia. Yakut Medical Journal. 2010;(2):77-79. (In Russ.)
Views:
15
Email this article 