Features of the course of infectious diseases of viral etiology with neutropenia
https://doi.org/10.1234/YMJ.2022.77.05
Abstract
The aim of the study is to establish the features of the course of infection of viral etiology with neutropenia. Study included analysis of immunological parameters of 628 people with a viral infection and 359 practically healthy people aged 31-51 years living in Arkhangelsk. It was found that the course of infection of viral etiology against the background of neutropenia is accompanied by a more significant decrease in the percentage of active phagocytes and an increase in the concentration of circulating immune complexes, which occurs against the background of a low content of properdin, which is a risk of a chronic course of the disease. The deficiency of the phagocytic activity of neutrophils in neutropenia is due to the insufficiency of the main chemotaxis factor C5a, which is a product of the enzymatic cleavage of C5. An increase in the content of autoantibodies, which is characteristic of viral pathology, speaks in favor of a more significant level of cytolytic and secretory function of neutrophils in neutropenia.
Supporting agencies: The study was performed under the program of fundamental scientific research, № 122011800217-9.
About the Authors
L. К. Dobrodeeva
Institute of Physiology of Natural Adaptations
Russian Federation
Russian Federation
Liliya K. Dobrodeeva – Doctor of Medical Sciences, Professor, Chief Researcher of the laboratory of regulatory mechanisms of immunity, Director of the Institute of Physiology of Natural Adaptations.
Office phone: (8182) 652992
S. N. Balashova
Institute of Physiology of Natural Adaptations
Russian Federation
Russian Federation
Svetlana N. Balashova – Candidate of Biological Sciences, senior researcher of the laboratory of regulatory mechanisms of immunity of the Institute of Physiology of Natural Adaptations.
Office phone: (8182) 21-04-58
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Review
For citations:
Dobrodeeva L.К., Balashova S.N. Features of the course of infectious diseases of viral etiology with neutropenia. Yakut Medical Journal. 2022;(1):19-23. https://doi.org/10.1234/YMJ.2022.77.05
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