Влияние COVID-19 на изменение когнитивных функций
https://doi.org/10.25789/YMJ.2023.81.25
Аннотация
Сделано предположение, что когнитивные нарушения у людей, перенесших COVID-19, обусловлены изменением эпигенетической регуляции нейронов головного мозга вследствие активации ретроэлементов под влиянием вируса SARS-CoV-2. С целью подтверждения роли транспозонов в изменении функционирования головного мозга у больных COVID-19 исследована научная литература и результаты мета-анализов за последние 3 года. Выявлено, что SARS-CoV-2 оказывает влияние на головной мозг не только за счет прямого воздействия, индукции воспаления и коагулопатии, но и путем активации ретроэлементов, транскрипты которых процессируются в микроРНК. Это отражается на изменениях эпигенетической регуляции генов в нейронах головного мозга, что, в свою очередь, отражается на когнитивных функциях. Ретроэлементы способствуют инсерциям в геном человека к ДНК вируса SARS-CoV-2, которые являются причинами развития долговременных изменений когнитивных функций у перенесших COVID-19 пациентов.
При поддержке: Работа выполнена в рамках государственного задания Минобрнауки РФ (№АААА-А16-116020350032-1) при частичной поддержке мегагранта Правительства Республики Башкортостан и гранта Российского научного фонда (проект № 17-78-30028).
Об авторах
Р. Н. Мустафин
Башкирский ГМУ
Россия
Россия
Мустафин Рустам Наилевич – к.м.н., доцент
А. В. Казанцева
Институт биохимии и генетики – обособленного структурного подразделения Уфимского ФИЦ РАН; Уфимский университет науки и технологий
Россия
Россия
Казанцева Анастасия Валерьевна – к.б.н., с.н.с.
Э. К. Хуснутдинова
Института биохимии и генетики УФИЦ РАН; Уфимский университет науки и технологий
Россия
Россия
Хуснутдинова Эльза Камилевна – д.б.н., проф., чл.-корр. РАО, директор; зав. кафедрой
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Рецензия
Для цитирования:
Мустафин Р.Н., Казанцева А.В., Хуснутдинова Э.К. Влияние COVID-19 на изменение когнитивных функций. Якутский медицинский журнал. 2023;(1):100-105. https://doi.org/10.25789/YMJ.2023.81.25
For citation:
Mustafin R.N., Kazantseva A.V., Khusnutdinova E.K. The role of COVID-19 in modified cognitive functioning. Yakut Medical Journal. 2023;(1):100-105. https://doi.org/10.25789/YMJ.2023.81.25
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