Affinoleukin application in complex treatment of lungs tuberculosis in teenagers
Abstract
The clinical and immunocorrective efficacy of the immunotherapeutic drug Affinoleukin (AFL) in the complex treatment of pulmonary tuberculosis in adolescents is investigated. At the immunological study in patients treated with AFL a specific increase in antigen-induced production of interferongamma (IFN-g) in samples of whole blood in vitro was determined; at the immunophenotyping – increase in the percentage of circulating gammadelta T-lymphocytes and a decrease in the subpopulation proportion of IFN-g - producing gamma-delta T-lymphocytes, including antigen-induced ones in vitro was noted. It is assumed that AFL increases the migration of effector gamma-delta cells in the foci of tuberculosis inflammation.
About the Authors
L. I. Mordovskaja
ГУ НПЦ «Фтизиатрия» МЗ РС (Я)
Russian Federation
Russian Federation
V. A. Aksenova
НИИ фтизиопульмонологии ММА им. И.М. Сеченова
Russian Federation
Russian Federation
T. N. Arefyevа
Российский кардиологический научно-производственный центр РАМН
Russian Federation
Russian Federation
A. N. Mats
ГУ НИИ вакцин и сывороток им. И.И. Мечникова РАМН
Russian Federation
Russian Federation
M. A. Vladimirskij
НИИ фтизиопульмонологии ММА им. И.М. Сеченова
Russian Federation
Russian Federation
References
1. Значение антиген-индуцированной продукции интерферона-γ in vitro при лечении туберкулеза легких у подростков / Л.И.Мордовская [и др.] // Иммунология. - 2009. - Т. 30, №4. – С.220 – 223.
2. Иммунотерапевтическая эффективность аффинолейкина при атопическом дерматите / Е.В. Задионченко [и др.] //Биопрепараты. – 2004.- № 4 (16). - С. 25 – 31.
3. Индукция интерферона-гамма в образцах цельной крови in vitro – тест для определения туберкулезного инфицирования детей и подростков / Л.И.Мордовская [и др.] // Проблемы туберкулеза и болезней легких. - 2009.- №6. – С.19-24.
4. Мац А.Н. Природа «Трансфер-факторной» активности иммунотерапевтического препарата «аффинолейкин» / А.Н. Мац // Биопрепараты. – 2004. - №4 (16). – С.5-31.
5. Chen Z. Short analytical review. Immune regulation of γ/δ T cells responses in mycobacterial infections / Z. Chen // Clin. Immunology. - 2005.- Vol.116. - P. 202-207.
6. Differentiation of effectory memory V delta2 T cells and migratory routes in lymph nodes or inflammatory sites / F.Dieli [et al.] // J. Exp. Med. – 2003. – Vol. 18, №3. – P. 391-397.
7. Disease-specific changes in gammadelta T cell repertoire and function in patients with pulmonary tuberculosis / B.Li [et al.] // J.Immunol.– 1996. – Vol.157, №9. - Р. 4222-4229.
8. Evidence for the involvement of lung-specific gammadelta T cell subsets in local responses to Streptococcus pneumoniae infection / A.C. Kirby[et al.] // Eur. J. Immunol. – 2007. – Vol. 37, №12. – Р.3404-3413.
9. Gamma delta T cell responses associated with the development of tuberculosis in health care workers / D.J.Ordway [et al.] // FEMSImmunol. Med. Microbiol. – 2005. - Vol.143, №3. - P.339-350.
10. Macrophages exposed to Mycobacterium tuberculosis release chemokines able to recruit selected leucocyte subpopulations: focus on gammadelta cells / E. Ferrero [et al.] // Immunology. – 2003. - Vol.108, №3. - P.365-374.
11. Pulmonary V gamma 4+ gamma delta T cells have proinflammatory and antiviral effects in viral lung disease / J, Dodd [et al.] // J. Immunol. – 2009. – Vol. 182, №2. – Р.1174-1181.
12. Vgamma9/Vdelta2 T lymphocytes reduce the viability of intracellular Mycobacterium tuberculosis / F. Dieli [et al.] // Eur. J. Immunol. – 2000. - Vol.30, №5. - Р.1512-1519.
Review
For citations:
Mordovskaja L.I., Aksenova V.A., Arefyevа T.N., Mats A.N., Vladimirskij M.A. Affinoleukin application in complex treatment of lungs tuberculosis in teenagers. Yakut Medical Journal. 2010;(2):16-18. (In Russ.)
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