Glutathione and lipid peroxidation levels in the blood of lung cancer patients
https://doi.org/10.25789/YMJ.2024.86.07
Abstract
Lung cancer is one of the most commonly diagnosed malignant tumors worldwide and is characterized by high mortality. Lipid peroxidation plays a very important role in the development and progression of lung cancer. In this regard, the purpose of this study was to evaluate the status of lipid peroxidation and the glutathione system in patients with lung cancer depending on the histological form and stage of the disease.
In this work, 100 people with lung cancer with various histological forms and stages of the disease were examined. The intensity of free radical oxidation of lipids was assessed by the accumulation of malondialdehyde. The indicators of the glutathione system were assessed by the concentration of the reduced form of glutathione and the activity of enzymes: glutathione peroxidase, glutathione reductase, glutathione transferase.
Our data indicate that as the clinical stage of lung cancer develops, the level of lipid peroxidation increases, against the background of inhibition of the glutathione system (decreased glutathione reductase activity). Higher levels of malondialdehyde in patients with adenocarcinoma suggest that tumor development may be more closely related to oxidative stress.
About the Authors
E. K. Rumyantsev
Yakut Science Centre for Complex Medical Problems
Russian Federation
Russian Federation
Rumyantsev Egor Konstantinovich – junior researcher, Arctic Medical Center.
Yakutsk
E. V. Tomtosova
Yakut Science Centre for Complex Medical Problems
Russian Federation
Russian Federation
Tomtosova Eugenia Viktorovna – junior researcher, Epidemiology of Chronic Non-Infectious Diseases Department
Yakutsk
V. M. Nikolaev
Yakut Science Centre for Complex Medical Problems
Russian Federation
Russian Federation
Nikolaev Vyacheslav Mikhailovich – PhD in Biology, senior researcher, Epidemiology of Chronic Non-Infectious Diseases Department.
Yakutsk
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Review
For citations:
Rumyantsev E.K., Tomtosova E.V., Nikolaev V.M. Glutathione and lipid peroxidation levels in the blood of lung cancer patients. Yakut Medical Journal. 2024;(2):31-34. https://doi.org/10.25789/YMJ.2024.86.07
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