Study of genes-candidates polymorphism of susceptibility to tuberculosis in the different ethno-territorial groups of the RF
Abstract
The variability of polymorphic variants of three interleukine genes (rs1143634 in the gene IL1B, rs3212227 in IL12B gene and rs2234663 in the gene IL1RN) in Yakuts is characterized. Associations of studied polymorphic variants with pulmonary tuberculosis in Yakuts are not revealed. A comparison of allele and genotype frequencies between groups of TB patients and between control groups of three ethnoses (Russians, Tuvinians and Yakuts) of Siberia is held. It was shown that the differences between the samples of patients from different ethnic groups were of different nature (variability of allele frequencies and genotypes) than at comparing population samples. These differences in the level of differentiation between groups of patients and control of different ethnicities suggest the existence of racial specificity of the frequency distribution of alleles and genotypes of the investigated genes-candidates of susceptibility to tuberculosis.
About the Authors
N. P. Babushkina
НИИ медицинской генетики ТНЦ СО РАМН
Russian Federation
Russian Federation
A. A. Rudko
НИИ медицинской генетики ТНЦ СО РАМН
Russian Federation
Russian Federation
M. B. Freidin
НИИ медицинской генетики ТНЦ СО РАМН
Russian Federation
Russian Federation
A. N. Kucher
НИИ медицинской генетики ТНЦ СО РАМН
Russian Federation
Russian Federation
V. P. Puzyrev
НИИ медицинской генетики ТНЦ СО РАМН
Russian Federation
Russian Federation
E. S. Pavlova
НПЦ «Фтизиатрия» МЗ РС (Я)
Russian Federation
Russian Federation
E. A. Alexeeva
ЯНЦ КМП СО РАМН
Russian Federation
Russian Federation
E. F. Luginova
РДТС по лечебной работе
Russian Federation
Russian Federation
A. V. Gorokhov
ЯНЦ КМП СО РАМН
Russian Federation
Russian Federation
A. F. Kravchenko
НПЦ «Фтизиатрия» МЗ РС (Я)
Russian Federation
Russian Federation
N. R. Maksimova
ЯНЦ КМП;
РАМН
Russian Federation
Russian Federation
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Review
For citations:
Babushkina N.P., Rudko A.A., Freidin M.B., Kucher A.N., Puzyrev V.P., Pavlova E.S., Alexeeva E.A., Luginova E.F., Gorokhov A.V., Kravchenko A.F., Maksimova N.R. Study of genes-candidates polymorphism of susceptibility to tuberculosis in the different ethno-territorial groups of the RF. Yakut Medical Journal. 2010;(1):35-39. (In Russ.)
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