The rate and structure of the assortative marriages among deaf individuals in the Republic of Buryatia
https://doi.org/10.25789/YMJ.2024.86.04
Abstract
It is currently accepted that the reproductive capabilities of deaf people increase over time, and marriages between deaf people occur according to the principle of assortativity, which in total can lead to an increase in the frequency of one major autosomal recessive form of deafness. In this regard, the purpose of this work was to analyze the share and structure of assortative marriages based on deafness in the Republic of Buryatia. The sample of deaf individuals consisted of 201 people (113 female and 88 male) aged from 21 to 77 years (mean age 46.7 ± 7.9 years). For analysis of the marriage structure of deaf people, information was available for 168 marriages. Individuals were considered married if they had a registered marriage and/or if they had common children. An assortative marriage (AM) was a marriage in which both partners were deaf. An AM in which all the children were deaf was considered non-complementary, and an AM in which all the children were hearing was considered complementary. Marriages in which there were both hearing and deaf children were designated as segregating. An analysis of the marriage structure of deaf people showed that the proportion of marriages between deaf individuals in Buryatia is 81.8% (122 out of 149 marriages analyzed), and in 18.2% of cases (27 marriages) marriages were concluded between deaf and hearing people. Among all AM, the share of complementary marriages was 86.9% (106 out of 122), non-complementary 5.7% (7 out of 122) and segregating 7.3% (9 out of 122). It was revealed that with a high frequency of AM, the marital structure was characterized by a high proportion of complementary and low proportion of non-complementary and segregating AM, which may be explained by the peculiarities of the genetic structure of hereditary forms of hearing loss in the Republic of Buryatia.
About the Authors
G. P. Romanov
M.K. Ammosov North-Eastern Federal University (NEFU)
Russian Federation
Russian Federation
Romanov Georgy P. - researcher of the Research Laboratory of Molecular Biology
V. G. Pshennikova
Yakut Science Centre of Complex Medical Problems (YSC CMP)
Russian Federation
Russian Federation
Pshennikova Vera G. – Candidate of Biological Sciences, Leading Researcher of the Laboratory of Molecular Genetics
F. M. Teryutin
Yakut Science Centre of Complex Medical Problems (YSC CMP)
Russian Federation
Russian Federation
Teryutin Fedor V. – Candidate of Medical Scince, Researcher of the Laboratory of Molecular Genetics
A. V. Solovyev
M.K. Ammosov North-Eastern Federal University (NEFU)
Russian Federation
Russian Federation
Solovyev Aisen V. – Senior Researcher of the Research Laboratory of Molecular Biology
S. A. Fedorova
M.K. Ammosov North-Eastern Federal University (NEFU)
Russian Federation
Russian Federation
Fedorova Sardana A. – Dr. of Biological Sciences, Principal Researcher, Head of the Laboratory of Molecular Biology
N. A. Barashkov
Yakut Science Centre of Complex Medical Problems (YSC CMP)
Russian Federation
Russian Federation
Barashkov Nikolay A. – Candidate of Biological Sciences, Leading Researcher, Head of the Laboratory of Molecular Genetics
References
1. Marital structure, reproductive parameters and mutations of the GJB2 (Cx26) gene in deaf people in Yakutia / G.P. Romanov, N.A. Barashkov, F.M Teryutin [et al.] // Genetics. 2018. Vol.54, No. 5. P.547-555. DOI: 10.1134/S1022795418050071
2. Romanov G.P., Barashkov N.A. The role of assortative marriages due to deafness in the prevalence of hereditary hearing loss // Yakut Medical Journal. 2022. No. 4. P.96-100. DOI: 10.25789/YMJ.2022.80.25
3. The role of the social and demographic structure of communities of deaf people in the prevalence of inherited forms of hearing loss / O.L. Posukh, M.S. Bady-Khoo, M.V. Zytsar [et al.] // Vavilov. magazine genetics and selection. 2016. T. 20, No. 1. P. 7–15. doi.org/10.18699/VJ16/098
4. A Comparative Analysis of the Genetic Epidemiology of Deafness in the United States in Two Sets of Pedigrees Collected More than a Century Apart / K. S. Arnos, K. O. Welch, M. Tekin [et al.] // The American Journal of Human Genetics. 2008. V. 83. № 2. P. 200-207.
5. Agent-Based Modeling of Autosomal Recessive Deafness 1A (DFNB1A) Prevalence with Regard to Intensity of Selection Pressure in Isolated Human Population / G.P. Romanov, A.A. Smirnova, V.I. Zamyatin [et al.] // Biology-Basel. 2022; 11(2):257. DOI: 10.3390/biology11020257.
6. Autosomal recessive deafness 1A (DFNB1A) in Yakut population isolate in Eastern Siberia: extensive accumulation of the splice site mutation IVS1+1G>A in GJB2 gene as a result of founder effect / N.A. Barashkov, L.U. Dzhemileva, S.A. Fedorova [et al.] // Journal of Human Genetics. 2011. V. 56. № 9. P. 631-639.
7. Bell A. M. Visible speech: the science of universal alphabetics; or Self-interpreting physiological letters, for the writing of all languages in one alphabet / A. M. Bell, London: Simpkin, Marshall & Co., 1867. 126 c.
8. Carlsson P.-I. I. Marital status and birthrate of deaf people in two Swedish counties: The impact of social environment in terms of deaf community / P.-I. I. Carlsson, B. Danermark, E. Borg // American Annals of the Deaf. 2004. V. 149. № 5. P. 415-420.
9. Chaabani H. Genetic heterogeneity study of non-syndromic autosomal recessive sensorineural deafness within the Tunisian population / H. Chaabani, S. Ben Arab, K. Chebbi // Annales de genetique. 1995. V. 38, № 3. P. 158-61.
10. Deaf intermarriage has limited effect on the prevalence of recessive deafness and no effect on underlying allelic frequency / D. C. Braun, S. Jain, E. Epstein [et al.] // PLoS ONE. 2020. № 11 November (15). P. 1–13. https://doi.org/10.1371/journal.pone.0241609
11. Gray C. Reluctant Genius: Alexander Graham Bell and the Passion for Invention / C. Gray. New York : Arcade Pub, 2006. 466 с
12. GJB2 mutations in mongolia: Complex alleles, low frequency, and reduced fitness of the deaf / M. Tekin, X.-J. J. Xia, R. Erdenetungalag [et al.] // Annals of Human Genetics. 2010. V. 74. № 2. P. 155-164.
13. Fitness Among Individuals with Early Childhood Deafness: Studies in Alumni Families from Gallaudet University / S.H. Blanton, W.E. Nance, V.W. Norris [et al.] // Annals of Human Genetics. 2010. V. 74. № 1. P. 27-33.
14. Nance, W. E. Relation between choice of partner and high frequency of connexin-26 deafness / W.E. Nance, X.-Z. Liu, A. Pandya // The Lancet. 2000. V. 356. № 9228. P. 500-501.
15. Nance, W. E. Relevance of Connexin Deafness (DFNB1) to Human Evolution **This article represents the opinions of the authors and has not been peer-reviewed. / W. E. Nance, M. J. Kearsey // The American Journal of Human Genetics. 2004. V. 74. № 6. P. 1081-1087.
16. Role of DFNB1 mutations in hereditary hearing loss among assortative mating hearing impaired families from South India / P. Amritkumar, J.M. Jeffrey, J. Chandru [et al.] // BMC Med Genet 2018 Jun 19;19(1):105. doi: 10.1186/s12881-018-0609-6.
17. Stevenson, B. A. C. Hereditary Deaf Mutism, With Particular Reference To Northern Ireland / B. A. C. Stevenson, E. A. Cheeseman // Annals of Human Genetics. 1956. V. 20. № 3. P. 177-231.
18. Tekin M, Arici ZS. Genetic epidemiological studies of congenital/prelingual deafness in Turkey: population structure and mating type are major determinants of mutation identification. // Am J Med Genet A. 2007 Jul 15;143A(14):1583-91. doi: 10.1002/ajmg.a.31702.
19. The GJB2 (Cx26) Gene Variants in Patients with Hearing Impairment in the Baikal Lake Region (Russia) / V.G. Pshennikova, F.M. Teryutin, A.M. Cherdonova [et al.] // Genes. 2023, 14, 1001. doi: 10.3390/genes14051001.
Review
For citations:
Romanov G.P., Pshennikova V.G., Teryutin F.M., Solovyev A.V., Fedorova S.A., Barashkov N.A. The rate and structure of the assortative marriages among deaf individuals in the Republic of Buryatia. Yakut Medical Journal. 2024;(2):17-20. https://doi.org/10.25789/YMJ.2024.86.04
Views:
17
Email this article 