Metabolism features in the liver cells in children depending on the stage of chronic hepatitis B
Abstract
The study included 24 children between the ages 12 and 16 years, patients with chronic hepatitis B with the 2 stage and the 3 stage of the chronic process. in which a liver biopsy determined for the activity of NAD/F/-dependent enzymes and parameters of lipid profile. We found that the increase in chronic stage of infection was accompanied by a decrease in liver cells of cholesterol and phospholipids, lipid shift toward the formation of triacylglycerides, decreased activity of NADPH-dependent enzyme and decrease of the synthetic potential of cell metabolism and their proliferative capacity, a reduction in the protection of cells from peroxidation processes lipid reduction in their ATP production by inhibiting the reactions of the Krebs cycle and glycolysis.
About the Authors
V. G. Bulygin
Federal State Budgetary Institution Research Institute of Medical Problems of the North Siberian Office of the Russian Academy of Medical Science
Russian Federation
Russian Federation
Bulygin Vadim Gennadevich, the candidate of medical sciences, the leading researcher
660022, Krasnoyarsk, Partizana Zheleznyaka St., 3-g., ph. office. : (391)228-06-83
G. V. Bulygin
Public Educational Institution of Higher Professional Training Krasnoyarsk State Medical University named after prof. V.F. Vojno-Yasenetsky of the Ministry of Health and Social Development of the Russian Federation
Russian Federation
Russian Federation
Bulygin Gennady Viktorovich, doctor of medical sciences, professor, professor of chair of clinical immunology
References
1. Bulygin V.G. Metabolic parameters in lymphocytes of children and adults with chronic viral hepatitis B / V.G. Bulygin, E.P. Tikhonova, N.A. Aksenova, G.V. Bulygin // Siberian medical review. – 2010. – N2. – P. 33–36.
2. Bulygin G.V. Metabolic bases of regulation of the immune response / G.V. Bulygin, N.I. Kamzalakova, A.V. Andreychikov. – Novosibirsk, SB RAMS. – 1999. – 346 p.
3. Gunyakova V.K. Viral hepatitis B in children: clinical and epidemiological and social aspects / V.K. Gunyakova // Russian Journal of Pediatrics. – 2005. – N3. – P. 21–26.
4. Rebrova O.U. Statistical analysis of medical data: Application software package Statistica / O.U. Rebrova. – Moscow: Mediasphere, 2002. – 312 p.
5. Savchenko A.A. Highly sensitive determination of dehydrogenase activity in human peripheral blood lymphocytes by bioluminescent / A.A. Savchenko, L.N. Suntsova // Laboratory work. – 1989. – N11. – P. 23–25.
6. Serov V.V. Morphological criteria for assessing the etiology, and the degree of activity of the process in viral chronic hepatitis B and C / V.V. Serov, L.O. Severgina // Archives of Pathology. – 1996. – N4. – P. 61–64.
7. Solovyova I.A. Of the immune status in children with chronic viral hepatitis B and C / I.A. Solovieva, A.A. Savchenko, G.P. Martynova // Pacific Medical Journal. – 2010. – N1. – P.55–57.
8. Tikhonova E.P. Metabolic basis of immunoreactivity with parenteral hepatitis B and C / E.P. Tikhonova, G.V. Bulygin. – Novosibirsk: Nauka, 2003. – 148 p.
9. Shakhgildyan I.V. Chronic viral hepatitis in the Russian Federation / I.V. Shakhgildyan, A.A. Jasinski, M.I. Mikhailov et al. // Clinical and epidemiological and ethno-ecological problems of digestive diseases: Materials eighth East Siberian gastroenterology conference with international participation and the Krasnoyarsk regional gastroenterology conference., 17–18 April 2008 – Krasnoyarsk, 2008. – P. 246–253.
10. Shahanina I.L. Economic costs of infectious disease in Russia: the magnitude and trend / I.L. Shahanina., L.A. Osipova // Epidemiology and Infectious Diseases. – 2005. – N4. – P. 14–25.
11. Folch J. A simple method for the isolation and purification of total lipids from animal tissues / J. Folch, M. Lees, G. Sloane-Stanley // J. Biol. Chem. – 1957. – Vol. 226, N1. – P. 497–509.
Review
For citations:
Bulygin V.G., Bulygin G.V. Metabolism features in the liver cells in children depending on the stage of chronic hepatitis B. Yakut Medical Journal. 2013;(3):21-23.
Views:
14
Email this article 