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Association of uric acid with coronary atherosclerosis in the population of Yakutia

Abstract

Research objective was to estimate the uric acid levels in patients with the verified coronary atherosclerosis and persons without clinical signs of IHD, and also the frequency of the association of hyperuricemia with coronary atherosclerosis depending on ethnic and gender origin on the example of Yakutia population. Results of the survey of men and women at the age of 45-64 years of native and non-native population with the verified coronary atherosclerosis according to selective coronaroangiography, and also of persons without clinical signs of IHD, were analyzed. The results of the research showed that the uric acid levels were significantly higher in patients with the verified coronary atherosclerosis (excepting of women of non-native nationality) in comparison with persons without clinical signs of IHD and higher in representatives of non-native nationality, than in the native population of Yakutia.

About the Authors

A. N. Romanova
Yakut research centre of complex medical problems SB RAMS
Russian Federation

doctor of medical sciences, head of laboratory of clinical population investigations



M. I. Voevoda
Institute of Internal Medicine SB RAMS
Russian Federation

corresponding member of RAMS, doctor of medical sciences, professor, director



Z. N. Krivoshapkina
Yakut research centre of complex medical problems SB RAMS
Russian Federation

candidate of medical sciences, senior science assistant of department of studying of mechanisms adaptation



References

1. Donskov A.S. Uratе lesion of kidneys and metabolic shifts at patients with an arterial hypertension / A.C. Donskov, I.M. Balkarov, Z.M. Dadina // Therapeutic archive. – 1999. – №.6. – P.53–56.

2. Cardiorenal interactions: clinical value and role in pathogenesis of diseases of cardiovascular system and kidneys / N.A. Mukhin, S.V. Moiseyev, Z.D. Kobalava [et.] // Therapeutic archive. – 2004а1. – № 6. – P. 39–46.

3. Metabolic syndrome: influence of purine metabolism on its main components / T.N. Vasil’kova, S.I. Mataev, T.N. Popova, O.V. Kushnerchuk // Byulletin SB RAMS. – 2009. – №1. – P. 38–41.

4. Uric acid – a key component of “cardioreno-metabolic continuum” / Zh.D. Kobalava, Yu.V. Kotovskaya, V.V.Tolkacheva, A.S. Milto // Cardiovascular therapy and prevention. – 2008 . – № 7. – P. 95–100.

5. A causal role for uric acid in fructose– induced metabolic syndrome / T. Nakagawa, H. Hu, S. Zharikov [et al.] // Am. J. Physiol. Renal Physiol. – 2006. – Vol. 290. – P. F 625–F 631.

6. Adverse effects of the classical antioxidant uric acid in adipocytes: NADPH oxidase–mediated oxidative / nitrosative stress / Y.Y. Sautin, T. Nakagawa, S. Zharicov, R.J. Johnson // Am. J. Physiol. Cell Physiol. – 2007. – Vol. 293. – P.584–C 596.

7. Alderman M.H. Serum Uric Acid As a Cardiovascular Risk Factor for Heart Disease / M.H. Alderman // Current Hypertens Reports. – 2001. – № 3. – P. 184–189.

8. Cigarette smoking increases risk for incident metabolic syndrome in Chinese men-Shanghai diabetes study / Y. Zhu, M. Zhang, X. Hou [et al.] // Biomed. Environ. Sci. – 2011. – Vol. 24 (5). – P.475–482.

9. Gaffo A.L. Gout. Hyperuricemia and cardiovascular disease: how strong is the evidence for a causal link? / A. L. Gaffo, N.L. Edwards, K.G. Saag // Arthritis & Rheumatism. – 2009. – Vol. 11 (4). – P. 240–249.

10. Fang J. Serum uric acid and cardiovascular mortality–The NHANES I Epidemiologic Follow - up Study 1971–1992 / J. Fang, M. N. Alderman // JAMA. – 2000. – Vol. 283. P. 2404–2410.

11. Fessel W.J. High uric acid as an indicator of cardiovascular disease / W. J. Fessel // Am. J. Med. – 1980. – Vol. 68. – P. 401–404.

12. Is Hyperuricemia Another Facet of the Metabolic Syndrome? / T. - L. Liou, M. - W. Lin, L. - C. Hsiao [et al.] // J. Chin. Med. Assoc. – 2006. – Vol. 69 (3). – P. 104–109.

13. Is There a Pathogenetic Role for Uric Acid in Hypertension and Cardiovascular and Renal Disease? / R.J. Johnson, D.-H. Kang, D. Feig [et al.] // Hypertension. – 2003. – Vol. 41. – P.1183–1190.

14. Pathogenesis of essential hypertension: historical paradigms and modern insights / R.J. Johnson, D.I. Feig, T. Nakagawa [et al.] // J. Hypertens. – 2008. – Vol. 26. – P. 381–391.

15. Prevalence of the Metabolic Syndrome in Patients With Gout: The Third National Health and Nutrition Examination Survey / K. Hyon, C. Earl, S. Ford [et al.] // Arthritis & Rheumatism. – 2007. – Vol. 57 (1). – P. 109–115.

16. Serum uric acid and cardiovascular events in successfully treated hypertensive patients / M.H. Alderman, H. Cohen, S. Madhavean, S. Kivlighn // Hypertension. – 1999. – Vol. 34. – P.144–150.

17. Serum uric acid and risk of coronary heart disease : atherosclerosis risk in communities (ARIC) Study / J.T. Moriarity, A.R. Folsom, C. Iribarren [et al.] // Ann. Epidemiol. – 2000. – Vol. 10. – P.136–143.

18. Stamler J. Mortality of low risk and other men : 16 - year follow - up of 353.340 men screened for the Multiple Risk Factor Intervention Trial (MRIFT) / J. Stamler, J.D. Neaton, D. Wentworth. // Circulation. – 1994. – Vol. 89 (2). – Р. 2.

19. Uric acid, evolution and primitive cultures / R.J. Johnson, S. Titte, J.R. Cade [et al.] // Semin. Nephrol. – 2005. – Vol. 25. – P. 3–8.

20. Uric acid, hominoid evolution, and the pathogenesis of salt - sensitivity / S. Watanabe, D.H. Kang, L. Feng [et al.] // Hypertension. – 2002. – Vol. 40. – P. 355 –360.


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For citations:


Romanova A.N., Voevoda M.I., Krivoshapkina Z.N. Association of uric acid with coronary atherosclerosis in the population of Yakutia. Yakut Medical Journal. 2013;(2):28-31.

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ISSN 1813-1905 (Print)
ISSN 2312-1017 (Online)