Level of Regulatory T-lymphocytes (CD4+CD25+FoxP3+) in Patients with Unstable Angina
Abstract
The role of regulatory T-lymphocytes (Тreg-cells) in development of atherosclerotic damage of vascular wall is the subject of research of world leading laboratories. Тreg cells have been identified in atherosclerotic plaques of human carotid and coronary arteries. Males (n=16) aged, at the average, 61,5 ± 9,3 admitted to the intensive care unit diagnosed with unstable stenocardia and conditionally healthy males (n=8) at the similar age were included in the study. The results of the comparative analysis revealed that patients with unstable stenocardia showed a significant increase of Тreg cells (CD4+CD25+FoxP3+), and a tendency towards a decrease of Т helpers (CD4+). The increase of Тreg cells is likely to suppress a further activity of the atherosclerotic process through suppressed proliferation and activity of T-helpers The negative correlative link between Тreg cells (CD4+CD25+FoxP3+) and Т-helpers (CD4+), as well as a positive link between Тreg cells (CD4+CD25+FoxP3+) and ХС-ЛПНП have been identified.
About the Authors
I. N. Nikolaeva
Federal state-financed institution «Yakut Scientific Center for Complex Medical Problems», Siberian branch, Russian Academy of Medical Sciences
Russian Federation
Russian Federation
Nikolaeva Irina Nikolaevna – senior research worker, Immune Pathology Laboratory
Yakutsk, the Republic Sakha (Yakutia)
A. S. Gol’derova
Medical Academy
Russian Federation
Russian Federation
Gol’derova Aitalina Semenovna – Candidate of Medicine, head of Immunology Department
Yakutsk, the Republic Sakha (Yakutia)
Z. N. Krivoshapkina
Federal state-financed institution «Yakut Scientific Center for Complex Medical Problems», Siberian branch, Russian Academy of Medical Sciences
Russian Federation
Russian Federation
Candidate of Biology, senior research worker, Laboratory of biochemical mechanisms of adaptation, Immune Pathology Laboratory
Yakutsk, the Republic Sakha (Yakutia)
F. A. Zakharova
Ammosov North-Eastern Federal University
Russian Federation
Russian Federation
Doctor of Medicine, professor, Medical institute
Yakutsk, the Republic Sakha (Yakutia)
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Review
For citations:
Nikolaeva I.N., Gol’derova A.S., Krivoshapkina Z.N., Zakharova F.A. Level of Regulatory T-lymphocytes (CD4+CD25+FoxP3+) in Patients with Unstable Angina. Yakut Medical Journal. 2013;(2):24-26.
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