Frequency of interictal epileptiform discharges in slow sleep with relapse of tonic-conical seizures in adults with generalized epilepsy after withdrawal of antiepileptic drugs

Interictal epileptiform discharge rates (IED) were studied in slow-wave sleep phases (NREM) with recurrent tonic-clonic seizures with generalized onset (GTCS) in adults after withdrawal from antiepileptic drugs (AED) with the debut of idiopathic generalized epilepsy (IGE) before the onset of adult age (group A). The control group consisted of IGE patients with non-drug-induced remission of GTCS for more than 5 years (group B). Patients who had presented information on myoclonic seizures in adolescence constituted group 1, patients with isolated GTCS - group of probable IGE GTCS (group 2). For the entire period of registration of the slow wave sleep phase, the absolute number and rates of IED per hour of recording were higher in patients with recurrent GTCS and myoclonic seizures in the illness history compared to other groups. In patients with recurrent GTCS and myoclonic seizures in the history of the disease, the persistent increase in IED rates per hour to the deep wave sleep phase was observed compared to the other group of patients with IGE. The evaluation of the IED rates in the slow wave sleep phase can be performed in patients with IGE for the prediction of recurrent GTCS and the solution of the question of withdrawal from the AED.

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