Нарушение транспортной регуляции ионов и жидкости в легких при COVID-19
https://doi.org/10.1234/YMJ.2022.77.29
Аннотация
В статье рассмотрены научные данные, основанные на современной литературе о нарушении транспорта ионов и жидкости в легких при COVID-19. Авторы исследования считают, что ингибирование TRPV4 (осмотически активируемого канала, связанного с ваниллоидным рецептором 4) имеет важное терапевтическое значение у пациентов с COVID-19, в частности мощные перспективы для защиты альвеолярно-капиллярного барьера и даже для регенерации поврежденного барьера. Клиническое испытание I фазы с использованием селективного ингибитора TRPV4 продемонстрировало благоприятный профиль безопасности у здоровых добровольцев группы контроля и у пациентов, страдающих кардиогенным отеком легких. Защита альвеолярно-капиллярного барьера селективным ингибитором TRPV4 также была бы полезна для устранения возможного легочного фиброза как позднего последствия COVID-19.
Об авторах
И. А. Синякин
ФГБОУ ВО «Амурская ГМА»
Россия
Россия
Синякин Иван Алексеевич – студент.
Т. А. Баталова
ФГБОУ ВО «Амурская ГМА»
Россия
Россия
Баталова Татьяна Анатольевна – д.б.н., доцент, зав. кафедрой.
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Рецензия
Для цитирования:
Синякин И.А., Баталова Т.А. Нарушение транспортной регуляции ионов и жидкости в легких при COVID-19. Якутский медицинский журнал. 2022;(1):114-117. https://doi.org/10.1234/YMJ.2022.77.29
For citation:
Sinyakin I.A., Batalova T.A. Disruption of transport regulation of ions and fluid in the lungs with COVID-19. Yakut Medical Journal. 2022;(1):114-117. https://doi.org/10.1234/YMJ.2022.77.29
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