Genes-markers of peptic ulcer disease
Yu. R. Sagadatova,
A. G. Khasanov,
I. R. Gilyazova,
A. F. Badretdinov,
R. R. Fayazov,
I. F. Sufiyarov https://doi.org/10.1234/YMJ.2022.77.27
Abstract
The review presents the analysis of the literature on genetic studies devoted to candidate genes for peptic ulcer disease. All the materials of these publications can be combined into two large groups: studies devoted to investigation of peptic ulcer inducer genes and studies devoted to protective genes. The main groups of ulcer inducer genes (ABO, HLA, PSCA, IL-1B, IL1RN, IL-6, IL-8, IL-10, TNFα, TGF-b1, B1,2,3, CYP2C19, MMP-2, MMP-3, MMP-9, Toll,TLR4TLR9, MIF, MPO) and protectors (IL-1, IL-1RN, TNF, LTA, IL-1b, MMP-3) were identified, but most of the results obtained to date are inconsistent, poorly reproduced in ethnically diverse populations, which makes it relevant to study this problem among different groups living in the Russian Federation.
About the Authors
Yu. R. Sagadatova
Башкирский ГМУ
Russian Federation
Russian Federation
Yuliya R. Sagadatova – Postgraduate student of the Department of Surgical Diseases.
A. G. Khasanov
Башкирский ГМУ
Russian Federation
Russian Federation
Anvar G. Khasanov – Doctor of Medical Sciences, Professor, Head of the Department of Surgical Diseases.
I. R. Gilyazova
УФИЦ РАН
Russian Federation
Russian Federation
Irina R. Gilyazova – Candidate of Biological Sciences, Associate Professor of the Department of Medical Genetics and Fundamental Medicine of IDPO, senior research fellow.
A. F. Badretdinov
Башкирский ГМУ
Russian Federation
Russian Federation
Azamat F. Badretdinov – Candidate of Medical Sciences, Associate Professor of the Department of Surgical Diseases.
R. R. Fayazov
Башкирский ГМУ
Russian Federation
Russian Federation
Radik R. Fayazov – Doctor of Medical Sciences, Professor of the Department of Surgical Diseases.
I. F. Sufiyarov
Башкирский ГМУ
Russian Federation
Russian Federation
Ildar F. Sufiyarov – Doctor of Medical Sciences, Professor of the Department of Surgical Diseases, Dean of the Faculty of Pediatrics.
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Review
For citations:
Sagadatova Yu.R., Khasanov A.G., Gilyazova I.R., Badretdinov A.F., Fayazov R.R., Sufiyarov I.F. Genes-markers of peptic ulcer disease. Yakut Medical Journal. 2022;(1):108-111. https://doi.org/10.1234/YMJ.2022.77.27
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