Changes of organometric parameters of epididymis of experimental animals after administration of cyclophosphamide

Abstract

The aim of this study was to establish organometric features of testicle appendages of immature experimental animals after immunosuppression, simulating the negative impact of exogenous factors on the reproductive system. It was revealed that the testicle appendages of immature animals exhibit an active response to the «soft» immunosuppression. The most active change indicators of organ morphometry are established in the early period after the administration of cyclophosphamide, which is probably due to the imperfection of the structure and functioning of the immature testicle appendages, as well as changes in the immune organs as a constituent of one of the regulatory systems of the body. Leveling of morphometric changes in the later stages of observation can be associated with the normalization of the immune system and the development of adaptation mechanisms in the male reproductive system organs.