Genetic risks of development of pelvic organ prolapse recurrence after hysterectomies
Abstract
The study included women with pelvic organ prolapse (POP) in the age from 35 to 65 years after hysterectomy by vaginal access in connection with complete and incomplete uterine prolapse and vaginal walls. The greatest expression of tissue degradation we observed in women with POP due to elevated levels of MMP1 and MMP2; they had the lowest TIMP-1 content. It is found that among MMP3 polymorphisms with risk of POP homozygous 5A5A was associated, which increases expression of the gene that has proved its excessive effect on destruction of collagen type I or reduction of biodegradable ability. The low frequency of allele CC MMP2 gene (735C> T) in patients with POP gave reason to consider it as a marker of barrier of tissue biodegradation of the connecting core of the pelvic organs. The mutant allele of CT variant rs 2277698 TIMP-2 gene is more common in women with pelvic floor failure, but without statistically significant differences. Reducing the accumulation of TIMP-1 on the background of the high expression of metalloproteinases details pathobiochemistry of disorders at the pelvic dysfunction.
About the Authors
M. L. Khanzadyan
Russian Peoples Friendship University
Russian Federation
Russian Federation
Khanzadyan Marina Laertovna - PhD, associate professor of obstetrics, gynecology and reproductive medicine
117198, Moscow, ul. Maclay, 8. Tel. (495) 3214185, 89104445268
T. A. Demura
Medical University First MGMU named after Sechenov
Russian Federation
Russian Federation
Demura Tatyana Alexandrovna - MD, Professor of Pathological Anatomy of academician A.I. Strukov
Moscow, 119991, st Trubetskaya. d. 8
N. I. Duglas
Medical University FPOV FGAOU HPE « Ammosov North-Eastern Federal University “
Russian Federation
Russian Federation
Duglas Natalia Ivanovna, MD, Head of the Department of Obstetrics and Gynecology
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Review
For citations:
Khanzadyan M.L., Demura T.A., Duglas N.I. Genetic risks of development of pelvic organ prolapse recurrence after hysterectomies. Yakut Medical Journal. 2016;(4):19-22.
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