Characteristics of the main links of immunity and endometrial cytokines in women with reproductive disorders
https://doi.org/10.1234/YMJ.2022.77.20
Abstract
Introduction. The involvement of many systems and levels of regulation in the processes of fertilization and gestation makes one pay attention to the changes occurring at all its levels.
Aim: to study and analyze changes in the indices of general and local immunity in women of reproductive age for the pathogenetic substantiation of therapeutic measures for reproductive disorders.
Materials and methods. The study included 50 patients with and reproductive disorders. Thirty-one healthy women with preserved fertility entered the control group included. All respondents underwent a questionnaire survey; general clinical, gynecological and laboratory-instrumental examination was carried out. The study followed the ethical principles and was approved by the local Committee on Biomedical Ethics. Statistical processing of the data obtained was performed using the StatSoft Statistica 6.1 (USA).
Results. Evaluation of indicators of cellular and humoral links of immunity showed a significant increase in the concentration of CD3 + (T-lymphocytes), CD3 + CD8 + / CD45 + (T-suppressors), phagocytic activity of neutrophils, NST -test sp., Ig M, and an increase in the studied pro- and anti-inflammatory cytokines. In the endometrium, with persistence of an infectious agent, a significantly high concentration of IL-8 and a decrease in IL-1 (β) were revealed.
Conclusions. The presence of the pathogen in the endometrium is characterized by a significant activity of the pro – inflammatory cytokine IL-8 and a decrease in IL-1(β). A decrease in progesterone, cortisol, NST sp., an increase in CD3 + CD8 + / CD45 +, IL-6, IL-8 can be attributed to the markers of reproductive disorders.
About the Authors
I. N. Danusevich
Scientific Centre for Family Health and Human Reproduction Problems
Russian Federation
Russian Federation
Irina N. Danusevich – Doctor of Medical Sciences, Leading Research Officer at the Laboratory of Gynecological Endocrinology, Scientific Centre for Family Health and Human Reproduction Problems.
L. M. Lazareva
Scientific Centre for Family Health and Human Reproduction Problems
Russian Federation
Russian Federation
Lyudmila M. Lazareva – Candidate of Medical Sciences, Research Officer at the Laboratory of Gynecological Endocrinology, Scientific Centre for Family Health and Human Reproduction Problems.
U. M. Nemchenko
Scientific Сentre for Family Health and Human Reproduction Problems
Russian Federation
Russian Federation
Uliana M. Nemchenko – Cand.Sc. (Biol), Researcher at the laboratory for microecology and the microbiome of Scientific Сentre for Family Health and Human Reproduction Problems.
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Review
For citations:
Danusevich I.N., Lazareva L.M., Nemchenko U.M. Characteristics of the main links of immunity and endometrial cytokines in women with reproductive disorders. Yakut Medical Journal. 2022;(1):79-83. https://doi.org/10.1234/YMJ.2022.77.20
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