Comparison of anti-opisthorchiasis effect of praziquantel and complexes of albendazole with arabinogalactan
Abstract
We made the comparative assessment of efficiency of praziquantel and complexes of albendazole with arabinogalactan (ABZ-AG) on Opisthorchis felineus on model of experimental opisthorchiasis. The experiments were carried out on five groups of golden hamsters Mesocricetus auratus infected with O. felineus and receiving various doses of praziquantel and complexes of albendazole with arabinogalactan. The group of the animals infected with O. felineus who weren’t receiving anti-helminthes has been used as control. The obtained data indicate that efficiency of ABZ-AG complexes is similar to therapeutic efficiency of praziquantel. Thus, results of this study confirm a possibility of the development of drugs for treatment of opisthorchiasis on the basis of intermolecular ABZAG. Besides, as praziquantel and albendazole possess different mechanisms of action on helminths, it is possible to assume that combinatory action of a praziquantel and ABZ-AG complexes be more effective on O. felineu s than individual effects of these drugs.
Keywords
opisthorchiasis,
Opisthorchis felineus,
praziquantel,
albendazole,
intermolecularcomplexes of albendazole with arabinogalactan
Supporting agencies: Financial support for this study was provided in part by the Russian Foundation for Basic Research [RFBR # 16-04-00356аand RFBR # 15-0403551а], by an Integrative project # 19of the Siberian Branch of the Russian Academy of Sciences, and by State Project№0324-2015-0004 of the Federal Research Center Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences.
About the Authors
M. Y. Pakharukova
Federal State Budget Scientific Organization the Institute of Molecular Biology and Biophysics;
The Federal Research Center Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences
Russian Federation
Russian Federation
Mariya Y. Pakharukova, PhD, senior researcher
630117, Novosibirsk, Timakov Str, 2/12
630090, Novosibirsk, Ac. Lavtrentiev Per,10
A. V. Dushkin
Institute of Solid State Chemistry and Mechanochemistry of Siberian Branch of Russian Academy of Sciences
Russian Federation
Russian Federation
Alexander V. Dushkin, PhD, Leading Researcher
630128, Novosibirsk, Kutateladze Str, 18
V. A. Mordvinov
Federal State Budget Scientific Organization the Institute of Molecular Biology and Biophysics;
The Federal Research Center Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences Russia
Russian Federation
Russian Federation
Viatcheslav A. Mordvinov, PhD, Acting Director
630117, Novosibirsk, Timakov Str, 2/12;
Science Deputy Director
630090, Novosibirsk, Ac. Lavtrentiev Per, 10
References
1. Brazhnikova N.A. Cancer of liver, biliary tract and pancreas at chronic opisthorchiasis / N.A. Brazhnikova,M.V. Tolkaeva // Bull Sib Med. - 2002. - № 2. - P. 71-77.
2. Opisthorchis felineus (Rivolta, 1884) and Metorchis bilis (Braun, 1890) infections in population of some regions of the Ob river basin. E.N. Ilyinskikh, V.V. Novitsky, N.N. Ilyinskikh [et al.] // Med Parazitol (Mosk). – 2007. - №41. P. 55-64.
3. Opisthorchiasis in Tobolsk based on 1950- 1987 autopsy data / N.A. Zubov, E.S. Belikov, L.N. Zaĭtseva [et al.] // Med Parazitol (Mosk). – 1989. - № 5. – P. 10-3.
4. A Physicochemical and Pharmacological Study of the Newly Synthesized Complex of Albendazole and the Polysaccharide Arabinogalactan from Larch Wood / Y.S. Chistyachenko, E.S. Meteleva, M.Y. Pakharukova [et al.] // Current Drug Delivery. – 2016. - 12(5):477-90.
5. Advanced periductal fibrosis from infection with the carcinogenic human liver fluke Opisthorchis viverrini correlates with elevated levels of interleukin-6 / B. Sripa, E. Mairiang, B. Thinkhamrop [et al.] // Hepatology. – 2009. - 50(4):1273-1281.
6. King S. Trematodes of the family Opisthorchiidae: a minireview / S. King, T. Scholz // Korean Journal of Parasitology. – 2001. - 39(3):209-221.
7. Liver fluke induces cholangiocarcinoma / B. Sripa, S. Kaewkes, P. Sithithaworn [et al.] // PLOS Medicine. – 2007. - 4(7):e201.
8. Mordvinov V.A. The Digenea parasite Opisthorchis felineus: a target for the discovery and development of novel drugs / V.A. Mordvinov, D.P. Furman // Infectious Disorders - Drug Targets. – 2010. - 10(5):385-401.
9. Olliaro P. The little we know about the pharmacokinetics and pharmacodynamics of praziquantel (racemate and R-enantiomer) / P. Olliaro, P. Delgado-Romero, J. Keiser // Journal of Antimicrobial Chemotherapy. – 2014. - 69(4):863-70.
10. Physicochemical properties and antiopisthorchosis effect of mechanochemically synthesized supramolecular complexes of Albendazole with the polysaccharide Arabinogalactan from Larix sibirica and Larix gmelinii / Y.S. Chistyachenko, M.V. Khvostov, A.I. Belousov [et al.] // Doklady Biological Sciences. – 2014. - 456(1):212-4.
11. Sripa B. Localisation of parasite antigens and inflammatory responses in experimental opisthorchiasis / B. Sripa, S. Kaewkes // International Journal for Parasitology. – 2000. - 30(6):735-740.
12. The first comprehensive study of praziquantel effects in vivo and in vitro on European liver fluke Opisthorchis felineus (Trematoda) / M.Y. Pakharukova, A.G. Shilov, D.S. Pirozhkova [et al.] // International Journal of Antimicrobial Agents. – 2015. - 46(1):94-100.
13. Torgerson P.R. World Health Organization Estimates of the Global and Regional Disease Burden of 11 Foodborne Parasitic Diseases, 2010: A Data Synthesis / P.R. Torgerson, B. Devleesschauwer, N. Praet // PLOS Medicine. – 2015. - 12(12):e1001920.
14. Tselepatiotis E. A case of Opisthorchis felineus infestation in a pilot from Greece / E. Tselepatiotis, S. Mantadakis, S. Papoulis // Infection. – 2003. - 31(6):430-432.
Review
For citations:
Pakharukova M.Y., Dushkin A.V., Mordvinov V.A. Comparison of anti-opisthorchiasis effect of praziquantel and complexes of albendazole with arabinogalactan. Yakut Medical Journal. 2016;(2):72-75.
Views:
38
Email this article 