Erythrocyte membranes microviscosity in the population of Samburg village Yamalo-Nenets Autonomous Okrug
Abstract
We studied the indices of relative microviscosity of the erythrocyte membranes in the two groups of inhabitants of the village Sumburgh Yamalo-Nenets Autonomous District: indigenous (tundra and forest Nenets) and non – indigenous arrived from central Russia. We revealed a significant increase in microviscosity of lipid-lipid interactions in the native women aged 46-55 years (p<0.05) compared with the non – indigenous ones. Increased membrane microviscosity may obstruct erythrocytes passage through microcapillary channel and lead to the development of the northern hypoxia.
About the Authors
P. V. Mokrushnikov
Federal State Budgetary Scientific Institution “Research Institute of Biochemistry”;
FSBEI Novosibirsk State University of Architecture and Civil Engineering (Sibstrin)
Russian Federation
Russian Federation
Mokrushnikov Pavel Valentinovich Ph.D. (phys.-math.), Senior researcher, Laboratory of molecular cell biology;
Timakova str. 2, Novosibirsk 630117;
Associate professor, Chair of physics
Leningradskaya str. 113, Novosibirsk, 630008
L. P. Osipova
Federal State Budgetary Scientific Institution Federal Research Center Institute of Cytology and Genetics of Siberian Branch of the Russian Academy of Sciences
Russian Federation
Russian Federation
Osipova Lyudmila Pavlovna Ph.D. (biol.), Head of Laboratory of population ethnogenetics
Novosibirsk, 630090, Academician Lavrentyev Avenue, 10
T. V. Goltsova
Federal State Budgetary Scientific Institution “Research Institute of Biochemistry”
Russian Federation
Russian Federation
Goltsova Tatiana Vladimirovna Scientific Secretary
Timakova str. 2, Novosibirsk 630117
A. A. Rozumenko
Federal State Budgetary Scientific Institution “Research Institute of Biochemistry”
Russian Federation
Russian Federation
Rozumenko Aleksandr Anatolievich Ph.D. (biol.), Senior researcher, Laboratory of medical biotechnology
Timakova str. 2, Novosibirsk, 630117
References
1. Stress hormones and coronary syndrome X (experimental studies)/ L.E. Panin, P.V. Mokrushnikov, R.A. Knyazev [et al.] // Atherosclerosis. – 2012. – V. 8. – № 2. – Р. 5-13.
2. Dobretsov G.E. Fluorescent probes in the study of cells, membranes and lipoproteins / G.E. Dobretsov. – M.: Nauka, 1989. – 324 p.
3. Ishutina N.A. Lipid peroxidation and erythrocyte membrane microviscosity in women with acute herpes virus infection / N.A. Ishutina // DMZh. – 2012. – V. 34. – № 1. – Р. 59-61.
4. Kunitsyn V.G. Mechanism of erythrocyte microcirculation in capillary vessels at physiological changes of pH / V.G. Kunitsyn, P.V. Mokrushnikov, L.E. Panin // SNMZh. – 2007. – V. 5. – № 127. – P. 28 – 32.
5. Mokrushnikov P.V. The influence of pH on surface tension of suspended erythrocytes / P.V. Mokrushnikov // SNMZh. – 2010. – V.1. – № 147. – Р. 38 – 46.
6. Panin L.E. Homeostasis and problems of circumpolar medicine (methodological aspects of adaptation) / L.E. Panin // SNMZh. – 2010. – V. 30. – P. 6-11.
7. Panin L.E. Effects of synthetic vitamin E derivatives on the rheological properties of red blood cell membranes / L.E. Panin, P.V. Mokrushnikov// Vestn. Nov. Gosud. Ped. Univ. – 2013. – V. 5, № 15. – Р. 101-110.
8. A method for studying oxygen diffusion barrier in erythrocytes: Effects of haemoglobin content and membrane cholesterol l/ K. Kon, N. Maeda, M. Sekija [et al.] // J. Physiol. (Gr. Brit.). – 1980. – V. 309. – P. 569-590.
9. Decreased fluidity of isolated erythrocytemembranes in type 1 and type 2 diabetes. The effect of resorcylidene aminoguanidine/ I.Waczulikova, L.Sikurova, J. Carsky [et al.] // Gen. Physiol. Biophys. - 2000. – V. 19, №4. – P. 381-392.
10. Interaction mechanism of anabolic steroid hormones with structural components of erythrocyte membranes / L.E. Panin, P.V. Mokrushnikov, V.G. Kunitsyn [et al.] // Journal of Physical Chemistry B. – 2011. – V. 115. – P. 14969-14979.
11. The interaction mechanism of cortisol and catecholamines with structural components of erythrocyte membranes / L.E. Panin, P.V. Mokrushnikov, V.G. Kunitsyn [et al.] // Journal of physical chemistry B. - 2010. – V. 114. – P. 9462-9473.
12. Tsuda K. Insulin and membrane microviscosity of erythrocytes as risk factors for stroke / K. Tsuda // Stroke. - 2003. – V. 54, № 3. – Р. 154-159.
Review
For citations:
Mokrushnikov P.V., Osipova L.P., Goltsova T.V., Rozumenko A.A. Erythrocyte membranes microviscosity in the population of Samburg village Yamalo-Nenets Autonomous Okrug. Yakut Medical Journal. 2016;(2):15-16.
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