Pathogenetic Aspects of Nasal Lesions in Patients with Chronic Hepatitis C
Abstract
The article reflects the problem of nasal bleeding in patients with chronic hepatitis C. The purpose of the study was to determine the presence of the HCV virus fragments in nasal mucosa, changes in the local T-cell immunity, detection of morphological changes of the nasal mucosa in chronic viral hepatits C. The result revealed the presence of HCV nonstructural protein NS3, local activation of T-cell immunity and metaplasia of the epithelium of the nasal mucosa.
About the Authors
A. Z. Mestnikova
Mechnikov Northwestern State Medical University
Russian Federation
Russian Federation
Mestnikova Ainа Zakharovna – post-graduate student of the department of otorhinolaryngology
195067, St. Petersburg, Piskarevskiy pr., D. 47; tel .: (812) 543-94-13
S. A. Artushkin
Mechnikov Northwestern State Medical University
Russian Federation
Russian Federation
Artushkin Sergey Anatolevich – MD, Professor, Head of department of otorhinolaryngology
191015, St. Petersburg, ul.Kirochnaya, d. 41; tel .: (812) 303-50-00
V. K. Artushkina
Mechnikov Northwestern State Medical University
Russian Federation
Russian Federation
Artushkina Valentina Kuzminichna - PhD, Associate professor of the department of otorhinolaryngology
191015, St. Petersburg, ul.Kirochnaya, d. 41; tel.: (812) 303-50-00
References
1. Baykova T.A. The variety of extrahepatic manifestations of chronic viral hepatitis B and C, the general principles of treatment / T.A. Baykova, T.N. Lopatkina // Therapeutic archive. - 2013. - №4. - P. 106-107.
2. Baranov A.V. The contents of class Ig G antibodies to NS3, NS4 and NS5-antigens of the hepatitis C virus and HCV RNA in the serum of patients with latent chronic hepatitis / A.V. Baranov, L.V. Shishkina // Basic research: Con-ference materials. – М. – 2008. -№1. - P. 98-99.
3. Volkov A.G. Nosebleeds / A.G. Volkov, N.V. Boyko, V.V. Kiselev. - M.: Jagar. – 2002. – 270 p.
4. Dudanova O.P. Chronic hepatitis C: diagnosis and clinical features / O.P. Dudanova, O.I. Kiselev. - Petrozavodsk: Petrozavodsk State University Publishing House, 2013. - 112 p.
5. Palchun V.T. National manual of otorhinolaryngology / V.T. Palchun. – GEOTAR-Med, 2009. 960 p.
6. Palchun T.V. Otorhinolaryngology. Clinical recommendations / T.V. Palchun, A.I. Kryukov. - M.: GEOTAR Media, 2013. - 368 p.
7. Petrov V.V. Actual questions of pathogenesis of nasal hemorrhage/ V.V. Petrov // Clinical Medicine. – 2006. – V.84. (4). - P.13-17.
8. Radchenko V.G. Optimization of etiopathogenetic therapy of chronic hepatitis C / V.G. Radchenko, V.V. Stelmach, V.K. Kozlov. - St. Petersburg: Tactic studio, 2004. – 166 p.
9. Fundamentals of Clinical Immunology: translated from English / E. Chepel [et al.]. - M.: GEOTAR Media, 2008. – 416 p.
10. Characterization of hepatitis C virusinduced nasal mucosa remodelling / Amr ElShazly [etc.] // Histopathology. – 2010. - Vol. 57. - N3. – P. 488-492.
11. Epistaxis as an initial sign of hepatic disease/ Barrio J. [et al.] // An Pediatr (Barc) - 2009 Vol. 70. - Issue 6. - P. 599-601.
12. Hepatitis C virus induces nasal epithelial erosion and sub-epithelial rhinitis / Abbas F. [et al.] // Rhinology. – 2009. - Vol. 47 - №4. - P.438-443.
13. Hepatitis C virus NS3/4A protease inhibits complement activation by cleaving complement component 4 / Mawatari S. [et al.] // PLoS One. – 2013. - 8 (12).
14. Urvashi R. Epistaxis: Study of aetiology, site and side of bleeding / R. Urvashi, R. Zada, V.N. Chaturvedi // Indian Journal of Medical Science. -1999. – Vol.53. - Issue 12. - Р.545-552.
Review
For citations:
Mestnikova A.Z., Artushkin S.A., Artushkina V.K. Pathogenetic Aspects of Nasal Lesions in Patients with Chronic Hepatitis C. Yakut Medical Journal. 2016;(1):7-10.
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