Risk Factors of the Development and Rupture of Cerebral Aneurysms
Abstract
Background and purpose. This review examines the evidence of epidemiological, pathophysiological and genetic studies on the search for risk factors of non‐traumatic cerebral aneurysms and subarachnoid hemorrhage.
Summary of the review. The epidemiological studies indicate significant differences in the incidence of subarachnoid hemorrhage in different populations. No one of the established risk factors can explain this phenomenon, and thus, likely there are other risk factors affecting the development of the disease. Mechanisms of aneurysm's development and rupture are not sufficiently clear currently. It was established the influence of genetic factors on the development of the cerebral aneurysms in many studies.
Conclusions. The data of recent studies suggest that the development and rupture of cerebral aneurysms are due to a complex interaction of modifiable factors and genetic predisposition. The discovery of new risk factors of the disease, including genetic ones, contributes to the understanding of mechanisms of cerebral aneurysms, and could be the basis for the prevention of subarachnoid hemorrhage.
About the Authors
S. A. Chugunova
North‐Eastern Federal University
Russian Federation
Russian Federation
Chugunova Sargylana Afanasyevna ‐ PhD, Associate Professor of Neurology and Psychiatry Department of the Institute of Medicine
Yakutsk
T. Ya. Nikolaeva
North‐Eastern Federal University
Russian Federation
Russian Federation
Nikolaeva Tatiana Yakovlevna ‐ Doctor of Medicine, Professor, Head of Department of Neurology and Psychiatry of the Institute of Medicine
Yakutsk
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Chugunova S.A., Nikolaeva T.Ya. Risk Factors of the Development and Rupture of Cerebral Aneurysms. Yakut Medical Journal. 2015;(4):98-102.
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