Background and purpose

ymj

Якутский медицинский журнал

Yakut Medical Journal

1813-19052312-1017

ЯНЦ КМП

ymj-1439

Research Article

НАУЧНЫЕ ОБЗОРЫ И ЛЕКЦИИ

SCIENTIFIC REVIEWS AND LECTURES

Факторы риска развития и разрыва церебральных аневризм

Risk Factors of the Development and Rupture of Cerebral Aneurysms

Чугунова

С. А.

Chugunova

S. A.

Чугунова Саргылана Афанасьевна – к.м.н., доцент, Медицинский институт

Chugunova Sargylana Afanasyevna ‐ PhD, Associate Professor of Neurology and Psychiatry Department of the Institute of Medicine

Yakutsk

sargyc@mail.ru

Николаева

Т. Я.

Nikolaeva

T. Ya.

Николаева Татьяна Яковлевна – д.м.н., проф., зав. кафедрой, Медицинский институт

Nikolaeva Tatiana Yakovlevna ‐ Doctor of Medicine, Professor, Head of Department of Neurology and Psychiatry of the Institute of Medicine

Yakutsk

СВФУ им. М.К. АммосоваРоссияNorth‐Eastern Federal UniversityRussian Federation

2015

13092025

0498102

2025

Чугунова С.А., Николаева Т.Я.

Chugunova S.A., Nikolaeva T.Y.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://ymj.elpub.ru/jour/article/view/1439

В обзоре рассматриваются данные эпидемиологических, патофизиологических и генетических исследований, посвященных поиску факторов риска развития нетравматических аневризм сосудов головного мозга и субарахноидального кровоизлияния. Результаты проведенных в последнее время исследований подтверждают, что формирование и разрыв церебральных аневризм происходит вследствие сложного взаимодействия модифицируемых факторов и генетической предрасположенности. Открытие новых факторов риска заболевания, в том числе генетических, вносит вклад в понимание механизмов развития церебральных аневризм, а также может стать основой для профилактики субарахноидального кровоизлияния.

Background and purpose

Background and purpose. This review examines the evidence of epidemiological, pathophysiological and genetic studies on the search for risk factors of non‐traumatic cerebral aneurysms and subarachnoid hemorrhage.

Summary of the review

Summary of the review. The epidemiological studies indicate significant differences in the incidence of subarachnoid hemorrhage in different populations. No one of the established risk factors can explain this phenomenon, and thus, likely there are other risk factors affecting the development of the disease. Mechanisms of aneurysm's development and rupture are not sufficiently clear currently. It was established the influence of genetic factors on the development of the cerebral aneurysms in many studies.

Conclusions

Conclusions. The data of recent studies suggest that the development and rupture of cerebral aneurysms are due to a complex interaction of modifiable factors and genetic predisposition. The discovery of new risk factors of the disease, including genetic ones, contributes to the understanding of mechanisms of cerebral aneurysms, and could be the basis for the prevention of subarachnoid hemorrhage.

церебральная аневризмасубарахноидальное кровоизлияниегенетика

cerebral aneurysmsubarachnoid hemorrhagegenetics

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The authors declare that there are no conflicts of interest present.