Molecular Genetic Studies of Hereditary Predisposition to Alcoholism
Abstract
The article presents a literature review on the results of molecular genetic studies of predisposition to alcoholism. Major molecular genetic studies of alcoholism conducted for identifying associations polymorphisms neurotransmitter system and ethanol - metabolizing enzymes in populations of different ethnic groups. Identification of gene polymorphisms association with the risk of developing alcoholism will promote preventive addictology and technologies of personalized therapy.
About the Authors
N. P. Matveeva
YSC CMP SB RAMS
Russian Federation
Russian Federation
Matveeva Nurguyana P., PhD, Head of Laboratory
N. V. Hoyutanova
YSC CMP SB RAMS; GBU Sakha (Yakutia) "YARND»
Russian Federation
Russian Federation
Hoyutanova Nadezhda V. -junior researcher, YSC CMP SB RAMS, psychiatrist, GBU Sakha (Yakutia) "YARND»
References
1. Anokhina I.P. Central mechanisms of susceptibility to substance dependence / I.P. Anokhina, N.L. Vekshina, A.G. Veretinskaya // Journal of Neurology and Psychiatry. – 1997. – pub. 12. – P.83-84.
2. Marusin A.V. The association of genetic polymorphism of the dopamine transporter DAT1 (SLC6A3) and ethanol-metabolizing enzymes ADH1B and CYP2E1 with the risk of formation of alcohol dependence in the Yakut population / A.V. Marusin, N.R. Maksimova, N.P. Matveeva [et al.] // Yakut medical journal. – 2009. – № 2. – P.148-150.
3. 5HTTLPR polymorphism of the serotonin transporter gene and G-703T polymorphism of tryptophan hydroxylase-2 in patients with alcoholism with antisocial behavior / V.A. Stoyak, S.I. Gusev, A.V. Kulikov [et al.] // Narcology- 2010: materials science and practical conference dedicated to the 25th anniversary of Federal Ministry of Russia NSC Addiction. – М. – 2010. – P. 142–143.
4. Faskhutdinova G.G. Molecular genetic study of substance dependence / G.G. Faskhutdinova// Phd thesis.— Ufa.- 2010.
5. Vasilieva E.D. Increased basal level of activity in Tryptophan prefer alcohol mice C57BI / E.D. Vasilieva, T.V. Yakovleva, S.I. Ilnickaya, G.V. Vasiliev // Bulletin of Experimental Biology and Medicine . – 2000. – V. 129. -№ 4. – P. 408-413.
6. Volkov A.N. The study of polymorphism RS 1611115 (1021S / T) gene dopamine-β- hydroxylase (DBN) in patients with alcoholic psychosis and healthy donors of Kemerovo region / A.N. Volkov, A.M. Seledsov, N.V. Somova // Siberian Herald of Psychiatry and Addiction. - 2013. – №2(77). – P.7-10.
7. Gavrilova V.A. Clinical and pathophysiological features of hormonal levels and gene polymorphisms in the serotonin system of alcoholics with an illegal act: synopsis of MD thesis / V.A. Gavrilova. – 2012.
8. Galeeva A.R. Rating VNTR-polymorphism in the dopamine transporter gene in men of different ethnicities with acute alcoholic psychosis/ A.R. Galeeva, E.B. Yuriev, E.K. Khusnutdinova // Journal of Neurology and Psychiatry. – 2001. – Iss. 5. – P. 43–52.
9. Gorbunova E.V. Investigation of a number of genes-candidates with acute alcoholic psychosis: synopsis of diss. thesis / E.V. Gorbunova. – 2002.
10. Zaynullina A.G. Haplotype association analysis of SLC6A3 gene with alcoholism in the population of the Yakut Republic of Sakha (Yakutia) and the Tatars of the Republic of Bashkortostan / A.G. Zaynullina, A.V. Kazanceva, S.S. Kulichkin, S.A. Fedorova, E.K. Khusnutdinova // Narcology. – 2010. – № 10. – P. 50–54.
11. Ivanov V.P. Influence of gene polymorphism of enzymes of alcohol metabolism on the risk of alcoholic psychosis / V.P.Ivanov, N.S. Kusheva // Narcology. – 2013. – №8. – P.51-54.
12. Fedorenko O.U. An investigation the association of polymorphic variants of the gene serum-and glucocorticoid-inducible kinase 1 with alcoholism / Fedorenko O.U., Boyarko E.G. [et al.] // Siberian Herald of Psychiatry and Addiction. -2013. – №5(80). – P.5-8.
13. Clinical and pathobiological regularities of alcoholism among the native population of the Republic of Sakha (Yakutia): results and prospects of interdisciplinary research / N.A. Bokhan, N.P. Matveeva, N.V. Khoyutanova [et al.] // Siberian Herald of Psychiatry and Addiction. – 2012. – №3(72). – P.21-28.
14. Kazanceva A.V. The role of the polymorphic VNTR locus DRD4 gene in the development of alcohol and drug addiction and the formation of personality traits in healthy individuals / A.V. Kazanceva, G.G. Faskhutdinova, S.S. Kulichkin, E.K. Khusnutdinova // Yakut medical journal. – 2009. – № 2. – P.107-110.
15. Kershengols B.M. Bienzyme dehydrogenase ethanol oxidation system and its role in the onset of alcoholism / B.M. Kershengols, V.G.Alekseev, R.S. Tazlova // Alcoholism biochemistry: Materials of VI All-Union. Symposium. – 1980. – Minsk-12p.
16. Kibitov A.O. Molecular genetic profile of mediator dopamine system in addicted patients / A.O. Kibitov // Siberian Herald of Psychiatry and Addiction. – 2013. – №1(76). – P.38-42.
17. Kulichkin S.S. Molecular genetic study of hereditary predisposition to alcoholism in populations of Yakut and Evenki Republic of Sakha (Yakutia) / S.S. Kulichkin, G.G. Faskhutdinova, A.V. Kazanceva, [et al.] // Narcology. – 2012. – №4. – P.48-54.
18. Matveeva N.P. Prevalence, risk factors and clinical dynamics of alcoholism and alcoholic psychosis among the indigenous population of the Republic of Sakha (Yakutia) (ethnocultural, rehabilitation aspects): PhD thesis / N.P. Matveeva. – 2010.
19. Marusin A.V. Gene polymorphism ethanolmetabolizing enzymes ADH1B, ADH7 and CYP2E1 and the risk of developing alcoholism in the Russian population of the West Siberian region / A.V. Marusin, V.A. Stepanov, M.G. Spiridonova [et al.] // Medical genetics. – 2006. – V. 5, № 7 (49). – P. 51–56.
20. Yuriev E.B. The analysis of genetic polymorphism associations in candidate genes neurotransmitter systems with acute alcoholic psychosis / PhD thesis E.B. Yuriev. – 2001.
21. Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region / K.P. Lesch, D. Bengel, A. Heils [et al.] // Science. – 1996. – V. 274(5292). – P. 1527-1531.
22. Evidence for genetic linkage to alcohol dependence on chromosomes 4 and 11 from an autosome-wide scan in an American Indian population / J.C. Long, W.C. Knowler, R.L. Hanson [et al.] // Am J Med Genet. – 1998. – Vol. 81(3). – P. 216–221.
23. Evidence for the importance of the human dopamine transporter gene for withdrawal symptomatology of alcoholics in a German population / C. Wernicke, M. Smolka, J. Gallinat [et al.] // Neuroscience Letters. – 2002. – Vol. 333 (1). – Р. 45–48.
24. Family – based and case – control study of DRD2, DAT, 5HTT, COMT genes polymorphisms in alcohol dependence / J. Samochowiec, M. J. Kucharska, A. Grzywacz [et al.] // Neurosci Lett. – 2006. – Vol. 410 (1). – P. 1–5.
25. Goldman D. The genetics of addictions: uncovering the genes / D. Goldman, G. Oroszi, F. Ducci // Nature reviews. Genetics. – 2005. – Vol. 6. – P. 521–532.
26. Gene – environment interaction between an aldehyde dehydrogenase – 2 (ALDH2) polymorphism and alcohol consumption for the risk of esophageal cancer / K. Matsuo, N. Hamajima, M. Shinoda [et al.] // Carcinogenesis. – 2001. – Vol. 22 – Р. 913–916.
27. Genome – wide search for genes affecting the risk for alcohol dependence / T. Reich, H.J. Edenberg, A. Goate [et al.] // Am. J. Med. Genet. – 1998. – Vol. 81 (3). – P. 207–215.
28. Interaction between the functional polymorphisms of the alcohol-metabolism genes in protection against alcoholism / C.C. Chen, R.B. Lu, Y.C. Chen [et al.] // Am. J. Hum. Genet. – 1999. – Vol. 65. – P. 795–807.
29. Interaction of the Effects of Alcohol Drinking and Polymorphisms in Alcohol – Metabolizing Enzymes on the Risk of Female Breast Cancer in Japan / T. Kawase, K. Matsuo, A. Hiraki [et al.] // J. Epidemiol. – 2009 – Vol. 19 (5) – Р. 244–250.
30. Kidd possible epistatic role of ADH7 in the protection against alcoholism / M.V. Osier, R.B. Lu, A. J. Pakstis [et al.] // Journal of Medical Genetics. – Part B. – Neuropsychiatric Genetics. – 2004. – Vol. 126B. – P. 19–22.
31. Oroszi G. Alcoholism: genes and mechanisms / G. Oroszi, D. Goldman // Pharmacogenomics. – 2004. – V. 5(8). – P. 1037–1048.
32. Shoshana H.S. ADH2 and Alcohol – Related Phenotypes in Ashkenazic Jewish American College Students / H.S. Shoshana, L.W. Tamara, G.C. Lucinda, K.L. Ting // Behavior Genetics. – 2001. – Vol. 31, № 2.
33. Tandem duplication polymorphism upstream of the dopamine D4 receptor gene (DRD4) / Seaman M.I. [et al.] // Am. J.Med.Genet. – 1999. – V.88 (6). – P.705-709.
34. The A9 allele of the dopamine transporter gene is associated with delirium tremens and alcohol withdrawal seizure / P. Gorwood, F. Limosin, P. Batel [et al.] // Biol Psychiat. – 2003 – Vol. 53. – Р. 85–92.
35. Teng Y.S. Human liver aldehyde dehydrogenase in Chinese and Asiatic Indians: gene deletion and its possible implications in alcohol metabolism / Y.S. Teng // Biochem. Genet. – 1981. – Vol. 19. – P. 107–114.
36. Trotter T. An essay, medical, philosophical, and chemical on Drunkenness and its effects on the human body / T. Trotter // Edited and with an introduction by Roy Porter. Tavistock Classics in the History of Psychiatry, London and New York: Routledge, 1988. xliv + 204 pp.
37. Association of µ-opioid receptor (OPRM1) gene polymorphism with response to naltrexone in alcohol dependence: a systematic review and meta-analysis/ A.-J. Chamorro, M. Marcos, J.-A. Mirón-Canelo [et al.] // Addiction Biology.- 2012.- V.17.- Issue 3.- P.505–512.
38. Li T. K. Annals New York Academy Sci./ T.K. Li, W.F. Bosron. - 1987.-Issue 492.- Р.1–9.
39. Mutations in the Gabrb1 gene promote alcohol consumption through increased tonic inhibition/ Q.M. Anstee, S.Knapp, E.P. Maguire [at al.] // Nature Communications.- 2013. - № 4.- Article number: 2816.
Review
For citations:
Matveeva N.P., Hoyutanova N.V. Molecular Genetic Studies of Hereditary Predisposition to Alcoholism. Yakut Medical Journal. 2014;(2):69-73.
Views:
5
Email this article 