LPLrs320 Lipoprotein Lipase Gene Polymorphism: Comparative Characteristics in Different Populations
Abstract
Gene LPL, encoding enzyme lipoprotein lipase, is the one of the most important genes associated with lipid disorders and the risk of metabolic syndrome. Earlier LPL rs320 gene polymorphism has been reported to be significantly associated with type 2 diabetes in the Yakut population. The aim of this study was to compare LPL rs320 SNP (G/T) allele frequency in different world populations, including the Yakuts and analyze blood glucose level, systolic blood pressure and body mass index in patients with type 2 diabetes and healthy individuals of Yakut ethnic group, depending on the genotype rs320 LPL. So the paper presents a comparison of allele frequencies SNP (G / T) gene LPL rs320, which contributes to the development of a predisposition to type 2 diabetes mellitus in the Yakut population, with distribution of allelic variants of this SNP in other world populations. Also the authors studied the blood glucose level, systolic blood pressure and body mass index, depending on the variant genotype rs320 LPL in patients with type 2 diabetes and healthy individuals of the Yakut ethnic group. The obtained during the study data reveal that in the Yakut population allele G variant rs320 LPL is most prevalent, with which a reduced risk of dyslipidemia and metabolic syndrome under the conditions of traditional nutrition type in the North with a high content of proteins and lipids is associated.
About the Authors
T. M. Sivtseva
Institute of Health NEFU named after M.K. Ammosov
Russian Federation
Russian Federation
Sivtseva Tatiana M., Ph.D., Senior Researcher, Laboratory of Genetic Research
677010 Yakutsk, Sergelyakhskoe Highway 4 km , Bld. C-2
A. I. Akimova
Institute of Health NEFU named after M.K. Ammosov
Russian Federation
Russian Federation
Akimova Alyona I., Junior Researcher, Laboratory of Genetic Research
677010 Yakutsk, Sergelyakhskoe Highway 4 km , Bld. C-2
V. L. Osakovskij
Institute of Health NEFU named after M.K. Ammosov
Russian Federation
Russian Federation
Osakovskij Vladimir L., PhD, Head of Laboratory of Genetic Research
677010 Yakutsk, Sergelyakhskoe Highway 4 km , Bld. C-2
L. G. Goldfarb
Institute of Neurological Disorders and Strokes USA Health National Institutes
United States
United States
Goldfarb Lev G., MD, Head of the Laboratory of Clinical Neurogenetics
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Review
For citations:
Sivtseva T.M., Akimova A.I., Osakovskij V.L., Goldfarb L.G. LPLrs320 Lipoprotein Lipase Gene Polymorphism: Comparative Characteristics in Different Populations. Yakut Medical Journal. 2014;(2):67-69.
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