Genetic Predisposition of Chronic Obstructive Pulmonary Disease in Extremely Cold Climate
Abstract
This article reflects the genetic aspects of chronic obstructive pulmonary disease. Modern molecular biology concept comes from an imbalance in the system proteolysis - antiproteoliz , alpha 1- antitrypsin is a major inhibitor of serine proteases, which include trypsin, chymotrypsin, neutrophil elastase, tissue kallikrin, Factor X "a" and plasminogen. The gene PI (proteinase inhibitor) located on the long arm of chromosome 14 (14q31- 32), and the gene product is glycoprotein alpha1 - antitryprisin. Two types of cells expressing the gene PI - macrophages and hepatocytes, the function of hepatocyte, associate tissue specificity of the inhibitor.
About the Authors
A. I. Sivtseva
Health NEFU named after M.K. Ammosov
Russian Federation
Russian Federation
Sivtseva Anna I. - MD, Leading Scientific Research Institute
677000, ul. Vinokourov 21 f. 24. Yakutsk
E. N. Sivtseva
NEFU named fter M.K. Ammosov
Russian Federation
Russian Federation
Sivtseva Elena N. – PhD, Senior Researcher Institute of Health
677000, ul. Pyotr Alexeyev, 73/2 f. 9 Yakutsk
M. V. Krivoshapkina
NEFU named after M.K. Ammosov
Russian Federation
Russian Federation
Krivoshapkina Marina V. - doctor - Physiotherapist Health Research Institute
Yakutsk
M. A. Ivanova
NEFU named after M.K. Ammosov
Russian Federation
Russian Federation
Ivanova Marianna A. - Junior Researcher Institute of Health
677005, ul. Lermontov 58, f. 32, Yakutsk
L. SS. Akimova
NEFU named after M.K. Ammosov
Russian Federation
Russian Federation
Akimova Laura S. - Junior Researcher Institute of Health
677000, Kalandarashvili 21/1, kv.38; Yakutsk
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Review
For citations:
Sivtseva A.I., Sivtseva E.N., Krivoshapkina M.V., Ivanova M.A., Akimova L.S. Genetic Predisposition of Chronic Obstructive Pulmonary Disease in Extremely Cold Climate. Yakut Medical Journal. 2014;(2):38-39.
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