Effect of Systemic Retinoids on Proteins Oxidative Modification during the Treatment of Patients with Acne in Dynamics
Abstract
32 patients with acne were surveyed to study changes in total protein oxidative modification of blood. Along with the generally accepted clinical and laboratory findings in patients electrophoresis of serum proteins by the severity of oxidative stress on the content of carbonyl derivatives (in spontaneous oxidative modification of proteins) was determined.
It is proved that the treatment of acne patients with systemic retinoids is accompanied by oxidative modification of serum proteins. The consequence of these processes can be aggravating oxidative stress and increased body harmful effects caused by free radicals in tissues.
Considering not sufficient study of the effects of systemic retinoid therapy, the treatment of acne should be strictly controlled, and in the selection of the dosage form should be dominated by the principles of more bioavailability and maximum effective dosage.
About the Authors
T. V. Kopytova
Laboratory Centre State Research Center of Dermatology and Cosmetology
Russian Federation
Russian Federation
Kopytova Tat'jana Viktorovna - Doctor biological Sciences, Head
603950, Russia, Nizhny Novgorod, Kovalikhinskaya street, 49 H
Tel.: (831) 419-64-35
E. V. Kotkova
Lobachevsky State University of Nizhny Novgorod; tate Research Center of Dermatology and Cosmetology
Russian Federation
Russian Federation
Kotkova Ekaterina Vasil'evna – рostgraduate of Molecular Biology and Immunology chair; biology
6030450, Nizhniy Novgorod, Gagarin’s avenue, 23;
603950, Nizhny Novgorod, Kovalikhinskaya street, 49 H
Tel.: (831) 419-64-35
N. A. Dobrotina
Nizhniy Novgorod state University, named after N.I. Lobachevcky - National research University
Russian Federation
Russian Federation
Dobrotyna Natalya Arkadyavna - Doctor medical Sciences, professor of molecular Biology and Immunology chair
Nizhniy Novgorod, 6030450, Russia, Nizhniy Novgorod, Gagarin’s avenue, 23, biological faculty
Tel.: (831) 465-82-07
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Review
For citations:
Kopytova T.V., Kotkova E.V., Dobrotina N.A. Effect of Systemic Retinoids on Proteins Oxidative Modification during the Treatment of Patients with Acne in Dynamics. Yakut Medical Journal. 2014;(4):11-14.
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