Dynamics of functional and morphological parameters of microcirculation in patients with non-alcoholic steatohepatitis due to an infectious mononucleosis
https://doi.org/10.25789/YMJ.2018.62.25
Abstract
The aim of our work was to assess the effectiveness using of the combination of a hepatoprotector phosfogliv and immunomodulator cycloferon on the state of functional and morphological parameters of microcirculation in patients with non-alcoholic steatohepatitis (NASH) after infectious mononucleosis (IM).
We examined 78 patients with a diagnosis of fatty liver disease after infection mononucleosis in age from 19 to 46 years, divided into two groups. The main group included 40 patients who received as therapy combination of drugs phosphogliv and cycloferon. The comparison group consisted of patients (n=38) who received conventional NASH treatment. To examine the state of microhemodynamics we used the slit lamp universal ml-2M, morphometry of capillaries of the nail bed capillaroscope carried the M-60 A.
For MCR morphological study we calculated indices of vascular, intravascular, extravascular disorders and General (integrated) conjunctival index using the formula KI. = КІ1+КІ2+КІ3. In the result, it was found that patients with fatty liver disease was due to infectious mononucleosis there are significant violations on the part of all departments of the MCR. Standard treatment for patients with this comorbid pathology improves morphological and functional parameters of microcirculation, but not effectively and rapidly than the combination of phosphoglyceride and cycloferon. So, using the combination of hepatoprotector phosphogliv and immunomodulator cycloferon in patients with fatty liver disease after infectious mononucleosis authentically significantly contributes the elimination of the phenomena of stasis and sludge syndrome in the arterioles and capillaries, and accelerate blood circulation.
About the Authors
A. V. Khabarova
Saint Luka LSMU
Ukraine
Ukraine
Habarova Alina Valer’evna, post-graduate student of V. M. Frolov Department of infectious diseases and epidemiology
Luhansk, Lyapina str. 2; code: 91002
telephone: + 380994911440.
Ya. A. Sotskaya
Saint Luka LSMU
Ukraine
Ukraine
Sotskaya Yana Anatol’evna, Doctor of Medical Sciences, Professor, head of V. M. Frolov Department of infectious diseases and epidemiology
Luhansk, Lyapina str. 2; code: 91002
телефон: +380509820895
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Review
For citations:
Khabarova A.V., Sotskaya Ya.A. Dynamics of functional and morphological parameters of microcirculation in patients with non-alcoholic steatohepatitis due to an infectious mononucleosis. Yakut Medical Journal. 2018;(2):85-88. https://doi.org/10.25789/YMJ.2018.62.25
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