Immune structures - cold - natural adaptogenes
Abstract
The article presents an analysis of literature data on the effect of cold on human health, the structure of the immune system, and the properties and effects of natural adaptogens.
In general, the general cryogenic climatic parameters of the Far North create uncomfortable conditions for human existence and affect people’s health. In extreme conditions, protective mechanisms and adaptive alteration of the body can lead to disruption – maladaptation. A whole series of pathological phenomena develops.
In modern conditions, the development of adaptogens from local raw materials for enhancing the body’s resistance, prevention and treatment of immune response disorders in low temperature conditions of the Sakha (Yakutia) Republic is a priority area.
About the Authors
A. I. FedorovaRussian Federation
Fedorova Aida Ivanovna, Candidate of Medical Sciences
+79241696871
D. K. Garmaeva
Russian Federation
Garmaeva Darima Kyshektovna, Doctor of Medical Sciences, Professor
+79142349680
L. I. Arzhakova
Russian Federation
Arzhakova Lena Ignatevna, Candidate of Medical Sciences
+79644150606
D. S. Belolubskaya
Russian Federation
Belolyubskaya Dariya Stepanovna, Candidate of Medical Sciences
+79142976118
O. G. Afanaseva
Russian Federation
Afanasyeva Oksana Gavrilovna, Candidate of Medical Sciences
+79142671992
A. I. Egorova
Russian Federation
Egorova Angelina Innokentievna, Candidate of Biological Sciences, Junior Research Associate
+79148220249
T. I. Dmitrieva
Russian Federation
Dmitrieva Tuyara Ivanovna, Candidate
+79644298776
I. P. Semyonov
Russian Federation
Semenov Ilya Petrovich, 2nd year student of “General Medicine”
+79246647537
A. P. Arzhakova
Russian Federation
Arzhakova Aleksandra Petrovna, Candidate of Sociological Sciences., Senior Associate
References
1. Agadzhanyan H.A., Petrova P. G. Chelovek v usloviyah Severa [Man in the North] Мoscow: - “KRUK” Publishing, 1996, 206 p.
2. Studencov E. P., Ramsh S.M., Kazurova N.G., Neporozhneva O.V., Garabadzhiu F.V., Kochina N.A., Voronkov N.G., Kuznetsov V.A., Krivorotov D.V. Adaptogeny i rodstvennye gruppy lekarstvennyh preparatov - 50 let poiskov [Adaptogens and Related Drug Groups – 50 Years of Research] Obzory po klinicheskoj farmakologii i lekarstvennoj terapii [Reviews of Clinical Pharmacology and Drug Therapy]. 2013, Vol. 11, No. 4, pp. 3-43.
3. Alekhin E.K., Lazareva D.N., Sibiryak S.V. Immunotropnye svojstva lekarstvennyh preparatov [Immunotropic Properties of Drugs]. Ufa: BGMI Publishing, 1993, 208 p.
4. Blyum V.S., Zabolotskij V.P. Immunnaya sistema i immunokompyuting [Immune system and Immunocomputing] Matematicheskaya morfologiya: Ehlektronnyj matematicheskij i medikobiologicheskij zhurnal [Mathematical Morphology: Electronic Mathematical and Medico-Biological Journal]. 2007, Vol. 6, issue 4, available at: http://www.sgma.alpha-design.ru
5. Buzinaeva M.T. Immunomorfologicheskaya harakteristika limfoidnoj tkani gortani pri vozdejstvii nizkih prirodnyh temperature: avtoref. dis. kand. med. nauk. [Immunomorphological characteristics of the laryngeal tissue of the larynx under the influence of low natural temperatures: Abstract of Ph.D. dissertation, pathological anatomy]. Ulyanovsk, 2013, 26 p.
6. Buyanov V.M. Limfologija endotoksikoza [Lymphology of endotoxicosis]. Moscow, Medicine, 1990, 272 p.
7. Varlamova N.G. Dinamika urovnya zdorovya u trudyashchihsya na Severe [Dynamics of Workers’ Health in the North] Adaptaciya i rezistentnost organizma na Severe [Adaptation and Resistance of Organism in the North]. Syktyvkar, 1990, pp. 64-73.
8. Selujko S.S., Gorbunov M.M., Namakonova V.S., Krasavina N.P. Vliyanie prirodnyh antioksidantov na regeneraciyu ehpiteliya slizistoj obolochki trahei pri obshchem ohlazhdenii organizma [Effect of Natural Antioxidants on Regeneration of the Mucous Membrane Trachea’s Epithelium with Overall Cooling of the Body] Dalnevostochnyj medicinskij zhurnal [Far Eastern Medical Journal]. 2014, No. 1, pp. 95-99.
9. Shapovalenko N.S., Dorovskikh V.A., Korshunova N.V., Shtarberg M.A., Slastin S.S., Nevmyvako E.E. Vliyanie holodovogo stressa na intensivnost perekisnogo okisleniya lipidov i antioksidantnuyu sistemu tkanej ehksperimentalnyh zhivotnyh [Effect of Cold stress on the Intensity of Lipid Peroxidation and the Antioxidant System of Experimental Animals] Byulleten̛ fiziologii i patologii dyhaniya [Physiology and Breathing Pathology Bulletin]. 2011, Vol. 39, pp. 22-25.
10. Volovich V.G. Chelovek v ehkstremalnyh usloviyah prirodnoj sredy [Man in Extreme Environmental Conditions]. Мoscow: Thought, 1983, 196 p.
11. Gavrilova M.K. Klimaty holodnyh regionov Zemli: ucheb. posobie [Climate of Cold Regions of the Earth: study guide]. Yakutsk: RAS SB Publishing, 2003, 208 p.
12. Garmaeva D.K., Osinskaja A.A., Sapin M.R. Limfoidnye struktury dyhatel’nyh putej pri vozdejstvii almaznoj pyli v uslovijah granil’nogo proizvodstva Respubliki Saha (Jakutija) v jeksperimente [Lymphoid structures of the airways under exposure of diamond dust in a lapidary industry of the Republic of Sakha (Yakutia) in the experiment]. Yakutsk, NEFU Publ., 2010, 278 p.
13. Li O.N., Dorovskikh V.A., Selujko S.S., Shtarberg M.A., Chzhou S.D., Li Ts Gistofiziologiya legkih krys pri holodovom vozdejstvii na fone vvedeniya arabinogalaktana [Histophysiology of Rat Lungs with Cold Exposure Given Administration of Arabinogalactan] Byulleten̛ fiziologii i patologii dyhaniya [Physiology and Breathing Pathology Bulletin]. 2011, No. 39, pp. 40-42.
14. Golderova A.C, Zaharova F.A., Alekseev S.N. Osobennosti nespecificheskoj adaptivnoj reakcii u bolnyh s ostroj holodovoj travmoj [Features of Nonspecific Adaptive Response in Patients with Acute Cold Trauma] Jakutskij medicinskij zhurnal [Yakut medical journal]. 2009, No. 1 (25), pp. 7-9.
15. Devonaev O.T. Strukturnofunkcionalnye harakteristiki i osobennosti morfogeneza limfoidnogo apparata mochevyvodyashchih putej v norme i pri vozdejstvii holodovogo stressa i vysokogorya: avtoref. dis…. dokt. med. nauk. [Structural and Functional Characteristics and Features of Morphogenesis of the Lymphoid Apparatus of the Urinary Tract in Normal Conditions and under the Influence of Cold Stress and High Altitude, Abstract of D. Sc. dissertation, Anatomy of Human]. Novosibirsk, 2007, 33 p.
16. Desyatov V. P. Smert ot pereohlazhdeniya organizma [Death by Hypothermia]. Tomsk, 1977, 128 p.
17. Ivanova R. N. Rekordno nizkie temperatury vozduha v Evrazii [Record Low Air Temperatures in Eurasia]. YSU Hearld. 2006, Vol. 3, No.1, pp. 13-19.
18. Kaznacheev V.P. Sovremennye aspekty adaptacii [Contemporary Aspects of Adaptation]. Novosibirsk: Science, 1980, 190 p.
19. Kalinyuk I.G. Morfologicheskie izmeneniya v limfoidnyh strukturah zheludka v dinamike postnatalnom ontogeneza v norme i pri antigennyj stimulyacii (ehksperimentalnoe issledovanie): dis ..kand. med. nauk [Morphological Changes in Lymphoid Structures of the Stomach in the Dynamics of Postnatal Ontogenesis in Normal Conditions and with Antigen Stimulation (experimental research)], Ph.D. Thesis, Anatomy of Human]. Uzhgorod, 2006, 178 p.
20. Krasavina N.P., Dorovskih V.A., Celujko S. S. Morfofunkcionalnaya harakteristika soedinitelnoj tkani organov dyhaniya pri obshchem ohlazhdenii organizma na fone medikamentoznoj korrekcii [Morphofunctional Characteristics of the Connective Tissue of the Respiratory Organs with General Cooling of the Body Against the Background of Drug Correction] Dalnevostochnyj medicinskij zhurnal.[Far Eastern Medical Journal]. 2002, No.1, p. 8.
21. Krivoshchekov S.G. Trud i zdorove cheloveka v Arktike [Work and Human Health in the Arctic] Zhurnal mediko-biologicheskih issledovanij [Journal of Biomedical Research]. 2016, No. 4, pp. 84-89.
22. Lazareva D.N., Alekhin E.K. Stimulyatory immuniteta [Stimulants of Immunoresistance]. Мoscow: Medicine, 1985, 256 p.
23. Garmaeva D.K., Fedorova A.I., Afanas’eva O.G., Sokolova R.G. Limfaticheskij uzel v jeksperimente: vospalenie, toksikoz, opuhol’ [The lymph node in the experiment: inflammation, toxicosis, tumor]. Novosibirsk, Manuscript Publ., 2005, 160 p.
24. Matkina O.V. Patogeneticheskie izmeneniya v timuse i selezenke neinbrednyh belyh krys pri ostrom stresse [Pathogenetic Changes in the Thymus and Spleen of Noninbred White Rats under Acute Stress] Permskij medicinskij zhurnal [Perm Medical Journal]. 2014, Vol. 31, No.1, pp. 121-128.
25. Li O.N., Dorovskikh V.A., Selujko S.S., Shtarberg M.A., Chzhou S.D., Li Ts Morfofunkcionalnaya ocenka trahei krys v modeli obshchego ohlazhdeniya organizma pri ispolzovanii arabinogalaktana [Morphofunctional Evaluation of Rat Trachea in the Model of General Body Cooling Using Arabinogalactan] Byulleten̛ fiziologii i patologii dyhaniya [Physiology and Breathing Pathology Bulletin]. 2011, No. 39, pp. 26 - 28.
26. Nikolaev V.M. Izmeneniya prooksidantno-antioksidantnogo ravnovesiya v otvetnyh ehkologobiohimicheskihreakciyah organizma zhivotnyh i cheloveka na dejstvie holoda: diss….. kand. biol. nauk [Changes in Prooxidant-Antioxidant Equilibrium in Response Ecologo-Biochemical Reactions of the Animal and Human Organisms to Cold Action, Ph.D. Thesis, Ecology]. Yakutsk, 2007, 112 p.
27. Obuhova L.A. Strukturnye preobrazovaniya v sisteme limfoidnyh organov pri dejstvii na organizm ehkstremalno nizkih temperatur i v usloviyah korrekcii adaptivnoj reakcii polifenolnymi soedineniyami rastitelnogo proiskhozhdeniya: avtoref. dis. dokt. med. nauk. [Structural Transformations in the System of Lymphoid Organs with the Action on the Organism of Extremely Low Temperatures and in Conditions of Correction of Adaptive Reaction by Polyphenolic Compounds of Plant Origin, Abstract of D. Sc. dissertation, Anatomy of Human]. Novosibirsk, 1998, 43 p.
28. Borodin Yu. I. Obshchaya anatomiya limfaticheskoj sistemy [General Anatomy of the Lymphatic System]. Novosibirsk: Science, 1990, 137 p.
29. Petrov R.V. Immunologiya [Immunology]. Мoscow: Medicine, 1982, 636 p.
30. Borodin Yu. I., Zykov A.A., Golovnyov V.A., Gorchakov V.N. Prirodnye bioflavonoidy kak sredstva dlya ehndoehkologicheskoj sanacii [Natural Bioflavonoids as Means for Endoecological Sanitation] Chelovek i lekarstvo: tez. dokl. V Rossijskogo nacionalnogo kongressa [Man and Medicine: theses of V Russian National Congress]. Moscow, 1998, p. 30.
31. Revich B.A. Izmenenie zdorovya naseleniya Rossii v usloviyah menyayushchegosya klimata [Changes in the Health of the Russian Population in Changing Climate] Problemy prognozirovaniya [Problems of Forecasting]. 2010, No. 3. – pp. 140- 150.
32. Sapin M.R., Nikitjuk D.B. Immunnaja sistema, stress i immunnodeficit [The immune system, stress and immunodeficiency]. Moscow, Dzhangar Publ., 2000, 184 p.
33. Semyonova I.B. Zakonomernosti korrekcii vtorichnyh immunodeficitov immunomodulyatorami (na primere anatoksina stafilokokkovogo ochishchennogo i likopida): dis… dokt. med. nauk. [Patterns of Correction of Secondary Immunodeficiencies by Immunomodulators (on the Example of Purified Staphylococcus Anatoxin and Lycopene), D. Sc. Thesis, Allergology and Immunology]. Moscow, 2004, 262 p.
34. Sepiashvili R.I. Funkcionalnaya sistema immunnogo gomeostaza [Functional System of Immune Homeostasis] Allergologiya i immunologiya [Allergology and Immunology]. 2015, Vol. 16. - No.1. - pp. 91-100.
35. Celujko S. S., Krasavina N.P., Semenov D.A., Gorbunov M.M., Chzhou S.D., Li Ts Sovremennye vzglyady na voprosy proliferacii i differencirovki stvolovyh kletok organov dyhaniya v norme i pri holodovyh vozdejstviyah [Modern Views on the Proliferation and Differentiation of Stem Cells of the Respiratory System in Norm and under Cold Influences] Byulletenʾ fiziologii i patologii dyhaniya [Physiology and Breathing Pathology Bulletin]. 2012, No. 45, pp. 98 -103.
36. Dobrodeeva L.K., Dyuzhikova E.M., Shegoleva L.V. Sostoyanie immunnoj sistemy u detej prozhivayushchih na severe v zonah razlichnoj stepeni diskomfortnosti [State of the Immune System in Children Living in the North in Zones of Varying Degrees of Discomfort] Immunologiya [Immunology]. 2004, No. 4, pp. 238 -242.
37. Savinov D.D., Petrova P. G., Zaharova F.A. [i dr.] Sreda obitaniya i zdorove cheloveka na Severe [Habitat and Human Health in the North]. Novosibirsk: Science, 2005, 291p.
38. Trufakin V. A., Robinson M.V. Morfocitohimicheskie metody dlya ocenki immunokompetentnyh kletok i limfoidnyh organov metodicheskie rekomendacii [Morphocytochemical Methods for Evaluation of Immunocompetent Cells and Lymphoid Organs: guidelines]. Novosibirsk, 1990, pp. 13-15.
39. Tumasov S.A. Smert ot ohlazhdeniya na Kamchatke [Death by Hypothermia in Kamchatka]. TSU Publishing, 1977, 26 p.
40. Tutelyan V.A. Biologicheski aktivnye dobavki - neizbezhnyj ehlement pishchi XXI veka [Biologically Active Additives – the Inevitable Element of Food of the XXI Century] BAD- nutrecevtiki i ih ispolzovanie s profilakticheskoj i lechebnoj celyu pri naibolee rasprostranennyh zabolevaniyah: III mezhdunarodnyj simpozium [BAA – Nutraceuticals and their Use with Preventive and Curative Purpose for Most Common Diseases: III International Symposium]. Tumen University Publishing, 1997, pp. 7-8.
41. Chava S.V Issledovanie perifericheskih organov immunnoj sistemy pri vvedenii v organizm immunomodulyatorov novogo pokoleniya (ehksperimentalno-morfologicheskoe issledovanie: dis… dokt .med. nauk. [Investigation of Peripheral Organs of the Immune System when New Immunomodulators are Introduced into the Body (Experimental Morphological Study), D. Sc. Thesis, Anatomy of Human]. Moscow, 2008, 524 p.
42. E. V. Kornienko Yakutiya: Istoriko-kulturnyj atlas [Yakutia: Historical and Cultural Atlas]. Moscow: Design Publishing. Information. Cartography, 2007, pp. 50-59.
43. Tarakanov A.O., Skormin V.A., Sokolova S.P. Immunocomputing: Principles and Applications. New York.: Springer, 2003, p. 230.
Review
For citations:
Fedorova A.I., Garmaeva D.K., Arzhakova L.I., Belolubskaya D.S., Afanaseva O.G., Egorova A.I., Dmitrieva T.I., Semyonov I.P., Arzhakova A.P. Immune structures - cold - natural adaptogenes. Yakut Medical Journal. 2018;(2):55-59.








