Polymorphism rs738409 of the adiponutrin gene (PNPLA3) among the indigenous residents of the North
https://doi.org/10.25789/YMJ.2018.62.14
Abstract
In this paper, we analyzed the polymorphism rs738409 of the adiponuclein gene (PNPLA3) among the indigenous inhabitants of the North of the Republic of Sakha (Yakutia). Under the constant influence of low temperatures, the human body needs a high level of energy metabolism, which in turn is accompanied by a significant consumption of lipids. Epidemiological data indicate the frequent combination of type 2 diabetes and non-alcoholic fatty liver disease (NAFLD) characterized by accumulation of lipids both in the hepatocytes themselves and in the intercellular space. Recently, great importance is attached to the genetic conditionality of NAFLD.
About the Authors
A. T. Dyakonova
FGBIU “Yakut Scientific Center of Complex Medical Problems”
Russian Federation
Russian Federation
D’yakonova Aleksandra Timofeevna – Junior researcher of the laboratory of heritable pathology
Tel.: 8 (914) 238 68 93
677010, Republic of Sakha (Yakutia), Yakutsk, Sergelyakhskoye shosse d.4
N. I. Pavlova
FGBIU “Yakut Scientific Center of Complex Medical Problems”
Russian Federation
Russian Federation
Pavlova Nadezhda Ivanovna – PhD, temporary acting chief scientific officer - head of the laboratory of heritable pathology
Tel.: +7 (914) 289 39 36
677010, Republic of Sakha (Yakutia), Yakutsk, Sergelyakhskoye shosse d.4
N. A. Solovyova
FGBIU “Yakut Scientific Center of Complex Medical Problems”
Russian Federation
Russian Federation
Solov’eva Natal’ya Alekseevna – PhD, temporary acting chief scientific officer - head of the Laboratory of Population Genetics
Tel.: 8 (924) 171 34 89
677010, Republic of Sakha (Yakutia), Yakutsk, Sergelyakhskoye shosse d.4
N. P. Filippova
FGBIU “Yakut Scientific Center of Complex Medical Problems”
Russian Federation
Russian Federation
Filippova Natal’ya Pavlovna – PhD, associate professor, senior researcher of the Laboratory of Population Genetics
Tel.: 8 (914) 303 43 95
677010, Republic of Sakha (Yakutia), Yakutsk, Sergelyakhskoye shosse d.4
V. V. Dodokhov
FGBIU “Yakut Scientific Center of Complex Medical Problems”
Russian Federation
Russian Federation
Dodokhov Vladimir Vladimirovich – PhD, researcher of the Laboratory of Population Genetics
Tel.: 8 (964) 422 02
677010, Republic of Sakha (Yakutia), Yakutsk, Sergelyakhskoye shosse d.4
L. M. Neustroeva
FGBIU “Yakut Scientific Center of Complex Medical Problems”
Russian Federation
Russian Federation
Neustroeva Lena Mikhaylovna– Junior researcher of the laboratory of the Laboratory of Population Genetics
Tel.: 8 (914) 825 26 01
677010, Republic of Sakha (Yakutia), Yakutsk, Sergelyakhskoye shosse d.4
M. A. Varlamova
FGBIU “Yakut Scientific Center of Complex Medical Problems”
Russian Federation
Russian Federation
Varlamova Marina Alekseevna – Junior researcher of the laboratory of heritable pathology
Tel.: 8 (914) 298 87 60
677010, Republic of Sakha (Yakutia), Yakutsk, Sergelyakhskoye shosse d.4
Kh. A. Kurtanov
FGBIU “Yakut Scientific Center of Complex Medical Problems”
Russian Federation
Russian Federation
Kurtanov Khariton Alekseevich – PhD, Chief Scientific Officer - Head of the Department of Molecular Genetics
Tel.: +7 (914) 106 00 3
677010, Republic of Sakha (Yakutia), Yakutsk, Sergelyakhskoye shosse d.4
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Review
For citations:
Dyakonova A.T., Pavlova N.I., Solovyova N.A., Filippova N.P., Dodokhov V.V., Neustroeva L.M., Varlamova M.A., Kurtanov Kh.A. Polymorphism rs738409 of the adiponutrin gene (PNPLA3) among the indigenous residents of the North. Yakut Medical Journal. 2018;(2):45-47. https://doi.org/10.25789/YMJ.2018.62.14
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