Biosynthetic processes in cardiomyocytes of albino rats after administration of dihydroquercetin
https://doi.org/10.25789/YMJ.2018.63.36
Abstract
The effect of dihydroquercetin (DHA) bioflavonoid in a dose of 50 mg/kg on DNA synthesis and the state of the nucleo-nucleolar apparatus of white rat cardiomyocytes on an intact background and under conditions of oxidative stress was studied. The corrective effect of DHA on biosynthetic processes in the myocardium of white rats in the presence of oxidative stress was revealed. The effect of DHA on an intact background inhibits DNA synthetic processes in the myocardium of newborn animals and reduces the size of nuclei and nucleoli in cardiomyocytes of sexually mature animals. The obtained data make it possible to recommend the use of antioxidants in cardiology only in the presence of pronounced oxidative stress.
About the Authors
E. N. Sazonova
FGBOU Far-Eastern Federal District of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Sazonova Elena Nikolaevna - MD, associate professor, pro-rector for science work, head of Department of normal and pathological physiology, Chief Researcher, Khabarovsk branch of the DNTS FPD - Research Institute for Maternity and Childhood Protection
Khabarovsk, MuravyevAmursky Str. 35
D. V. Yakovenko
FGBOU Far-Eastern Federal District of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Yakovenko Darya Valerevna - lecturer, Department of normal and pathological physiology
Khabarovsk, MuravyevAmursky Str. 35
O. A. Lebed’ko
FGBOU Far-Eastern Federal District of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Lebedko Olga Antonovna - MD, director of the Khabarovsk branch of the DNTS FPD - Research Institute for Maternal and Child Protection
Khabarovsk, MuravyevAmursky Str. 35
A. Yu. Marochko
FGBOU Far-Eastern Federal District of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Marochko Andrey Yurievich - MD, prof., Department of general and clinical surgery
Khabarovsk, MuravyevAmursky Str. 35
S. L. Zharskij
FGBOU Far-Eastern Federal District of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Zharsky Sergey Leonidovich - MD, prof., Head of chair of faculty therapy with the course of endocrinology
Khabarovsk, MuravyevAmursky Str. 35
V. A. Dobryh
FGBOU Far-Eastern Federal District of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Dobrykh Vyacheslav Anatolievich - MD, prof., Head of chair of propaedeutics of internal diseases with the course of phtisiatry
Khabarovsk, MuravyevAmursky Str. 35
M. F. Rzyankina
FGBOU Far-Eastern Federal District of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Rzyankina Marina Fedorovna - MD, prof., Head of chair of propaedeutics of internal diseases with the course of children’s infectious diseases
Khabarovsk, MuravyevAmursky Str. 35
T. V. Chepel’
FGBOU Far-Eastern Federal District of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Chepel Tatyana Vladimirovna - MD, associate professor, pro-rector for educational and pedagogical education work
Khabarovsk, MuravyevAmursky Str. 35
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Review
For citations:
Sazonova E.N., Yakovenko D.V., Lebed’ko O.A., Marochko A.Yu., Zharskij S.L., Dobryh V.A., Rzyankina M.F., Chepel’ T.V. Biosynthetic processes in cardiomyocytes of albino rats after administration of dihydroquercetin. Yakut Medical Journal. 2018;(3):109-112. https://doi.org/10.25789/YMJ.2018.63.36
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