A risk for congenital heart defects development associated with infectious factors in neonates of the Republic of Sakha (Yakutia)
https://doi.org/10.25789/YMJ.2019.68.17
Abstract
The article presents the results of a retrospective study on the role of pathogenic infectious factors on the probability of developing congenital heart disease (CHD) in newborn children in the Republic of Sakha (Yakutia).
We conducted an assessment of a number of anamnestic factors on the part of the mother: 1) the results of immunological tests for a number of infections (IgM and IgG to toxoplasmas, chlamydia, herpes simplex virus and cytomegalovirus); 2) various harmful factors of infectious genesis (recorded cases of SARS at various stages of pregnancy, viral hepatitis, tuberculosis, etc.).
We have found that cytomegalovirus infection, herpesvirus infection and acute respiratory viral infection in early pregnancy are a risk factor for congenital heart disease.
Supporting agencies: The project received financial support from the by RFBR according to the research project #18-05-60035_Arctica.
About the Authors
T. I. Nelunova
St.Petersburg state pediatric medical university
Russian Federation
Russian Federation
Nelunova Tuyara Ivanovna – postgraduate
St. Petersburg
T. E. Burtseva
North-Eastern federal university;
Yakut science center of complex medical problems
Russian Federation
Russian Federation
Burtseva Tatiana Egorovna – MD, professor of the department of pediatrics and pediatric surgery, Medical institute;
a head of the laboratory
Yakutsk
V. G. Chasnyk
St. Petersburg state pediatric medical university
Russian Federation
Russian Federation
Chasnyk Vyacheslav Grigorievich – MD, a head of the department of hospital pediatrics
St. Petersburg
S. S. Sleptsova
North-Eastern federal university;
Yakut science center of complex medical problems
Russian Federation
Russian Federation
Sleptsova Snezhana Spiridonovna – MD, associate professor, a head of the department of infectious diseases, phthisiology and dermatovenerology, Medical institute
a head of the laboratory
Yakutsk
M. P. Slobodchikova
St. Petersburg state pediatric medical university
Russian Federation
Russian Federation
Slobodchikova Maya Pavlovna – senior lecturer of the department of foreign languages with the course of Russian language
St. Petersburg
References
1. Osmirko T.V. Clinical and epidemiologic basis and assessment of risk factors for TORCH-syndrome neonates / T.V. Osmirko, L.V. Lyalina, V.O. Atlasov // Meditsinskiy almanakh. – 2015. − 40(5). – P. 75-79.
2. Yulish E.I. Congenital and acquired TORCH-infection in children / E.I. Yulish, A.P. Volosovets. – Donetsk: Region, 2005. – 216 р.
3. Park H.W. Chorioamnionitis and Patent Ductus Arteriosus: A Systematic Review and MetaAnalysis / H.W. Park, Y.S. Choi, K.S. Kim // PLoS One. – 2015. – Vol.10, №9. – e 0138114.
4. The influence of maternal exposure history to virus and medicine during pregnancy on congenital heart defects of fetus / Q. Liang, W. Gong, D. Zheng [et al.] // Environ Sci Pollut Res Int. 2016.
Review
For citations:
Nelunova T.I., Burtseva T.E., Chasnyk V.G., Sleptsova S.S., Slobodchikova M.P. A risk for congenital heart defects development associated with infectious factors in neonates of the Republic of Sakha (Yakutia). Yakut Medical Journal. 2019;(4):64-66. https://doi.org/10.25789/YMJ.2019.68.17
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