Features of immunogenetic status in children residing in nitrate geochemical province
https://doi.org/10.25789/YMJ.2019.68.14
Abstract
The authors assessed immunological and genetic status of children under excessive intake of nitrates with drinking water in a particular biogeochemical province of Perm region.
The changes in cellular component of the immune system (inhibition of T-cell receptors CD95+ and intracellular proteins Bcl2), TH deficiency, the increased expression of tumor markers associated with the growth in N-nitrosodimethylamine concentration in the blood, significant both in relation to the reference level and the comparison group were found. An increase in specific IgG to N-nitrosodimethylamine (p<0.05) was detected. The study results of the gene polymorphism frequency revealed its features in children of nitrate province according to the criterion of minor allele of genes: MTHFR, PPARA, CPOX, CYP1A2, BRCA1, which characterize the eventual violations of detoxification and cancer proliferation functions.
About the Authors
O. V. Dolgikh
FBSI "Federal Scientific Center for Medical and Preventive Health Risk Management Technologies"
Russian Federation
Russian Federation
Dolgikh Oleg Vladimirovich – Doctor of Medical Sciences, Head of the Department of Immunobiological Diagnostics
614045, Perm, 82 Monastyrskaya St. tel: (342) 236-39-30
T. S. Ulanova
FBSI "Federal Scientific Center for Medical and Preventive Health Risk Management Technologies"
Russian Federation
Russian Federation
Ulanova Tat'yana Sergeevna – Doctor of Medical Sciences, Head of Department of Analytical Chemistry Analysis
614045, Perm 82, Monastyrskaya St.; tel: (342) 236-39-30
I. N. Alikina
FBSI "Federal Scientific Center for Medical and Preventive Health Risk Management Technologies"
Russian Federation
Russian Federation
Alikina Inga Nikolaevna – junior research assistant of Department of Immunobiological Diagnostics
614045, Perm, 82 Monastyrskaya St.; tel: +7(342) 236-39-30
Yu. A. Chelakova
FBSI "Federal Scientific Center for Medical and Preventive Health Risk Management Technologies"
Russian Federation
Russian Federation
Chelakova Yuliya Aleksandrovna – junior research assistant of Department of Immunobiological Diagnostics
614045, Perm, 82 Monastyrskaya St.; tel: +7(342) 236-39-30
T. V. Nurislamova
FBSI "Federal Scientific Center for Medical and Preventive Health Risk Management Technologies"
Russian Federation
Russian Federation
Nurislamova Tat'yana Valentinovna – Doctor of Medical Sciences, Head of Gas Chromatography Laboratory
614045, Perm, 82, Monastyrskaya St.; tel: (342) 236-39-30
References
1. Nitrates and nitrites. Influence on the human body [Electronic resource.]-2009.URL: http://prodobavki.com/modules.php.article_id=96&name=articles.
2. Peculiarities of immune and genetic disadaptation in children under excess haptenic load / O.V. Dolgikh, N.V. Zaitseva, K.P. Luzhetskiy [et al.] // Rossijskij immunologicheskij zhurnal. – 2014. − №8 (3). – P. 299-302.
3. Calderon R. The epidemiology of chemical contaminants of drinking water / R. Calderon // Food and Chemical Toxicology. 2000; 38: 13-20. DOI: 10.1016/S0278-6915(99)00133-7.
4. Duramad P. Holland N.T. Biomarkers of immunotoxicity for environmental and public health research / P. Duramad, N.T. Holland. Int. J. Environ. Res. Public Health.2011; 8 (5): 1388-1401. 5. The emerging biology of the nitrite anion / M.T. Gladwin, A.N. Schechter, D.B. Kim-Shapiro [et al.] // Nature chemical biology. 2005; 1: 308–314.
Review
For citations:
Dolgikh O.V., Ulanova T.S., Alikina I.N., Chelakova Yu.A., Nurislamova T.V. Features of immunogenetic status in children residing in nitrate geochemical province. Yakut Medical Journal. 2019;(4):55-57. https://doi.org/10.25789/YMJ.2019.68.14
Views:
4
Email this article 