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Possibilities of prediction of neurotic, stress-related disorders course in terms of hormonal parameters

https://doi.org/10.25789/YMJ.2019.68.13

Abstract

We determined the contribution of the endocrine system to the formation of neurotic, stress-related disorders in order to identify the criteria for predicting their protracted course. A comprehensive clinical-psychopathological and hormonal examination of women with various types of the course of neurotic, stress-related disorders was performed. A psychopathological study of patients showed that overexertion of protective mental mechanisms associated with the impact of a stressful situation can lead to a breakdown in adaptation, disturbances of normal functioning and the emergence of various neurotic symptoms.
We determined the hormonal criteria for predicting a protracted course of neurotic, stress-related disorders with the formation of a persistent personality changes at an early stage of the disease - at the stage of disorder of adaptive reactions.

About the Authors

V. B. Nikitina
Tomsk National Research Medical Center of the Russian Academy of Sciences
Russian Federation

Nikitina Valentina Borisovna – MD, Head of the Laboratory of Clinical Psychoneuroimmunology and Neurobiology, Mental Health Research Institute

Aleutskaya Street 4, 634014, Tomsk. Tel.: +7(3822) 72-44-15



O. E. Perchatkina
Tomsk National Research Medical Center of the Russian Academy of Sciences
Russian Federation

Perchatkina Olga Ernstovna – PhD, Head of the Department of Coordination of Scientific Research, Mental Health Research Institute

Aleutskaya Street 4, 634014, Tomsk. Tel.: +7(3822) 72-35-16



M. M. Axenov
Tomsk National Research Medical Center of the Russian Academy of Sciences
Russian Federation

Axenov Mikhail Michailovich – MD, Prof., Head of Borderline States Department, Mental Health Research Institute

Aleutskaya Street 4, 634014, Tomsk. Tel.: +7(3822) 72-35-16



A. K. Kostin
Tomsk National Research Medical Center of the Russian Academy of Sciences
Russian Federation

Kostin Alexey Konstantinovich – PhD, senior researcher of Borderline States Department, Mental Health Research Institute

Aleutskaya Street 4, 634014, Tomsk. Tel.: +7(3822) 72-35-16



References

1. Baevskij R.M. Problem of health and norm: point of view of a physiologist / R.M. Baevskij // Clinical Medicine. – 2000. – № 4. – P. 59–64.

2. Kozlov A.I. Cortisol as a marker of stress / A.I. Kozlov, M.A. Kozlova // Human Physiology. – 2014. – № 2. – P. 123–136.

3. Kubasov R.V. The clinical laboratory characteristics of secretory function of thyroidal chain of regulation in individuals of dangerous professions / R.V. Kubasov, A.M. Ivanov, Ju.E. Barachevskij // Clinical Laboratory Diagnostics. – 2017. – № 2. – P. 103–107.

4. Malov Ju.S. Preliminary study of internal diseases. Manual for Graduate Students / Ju.S. Malov. – Saint-Petersburg: SpecLit, 2003. – 303 p.

5. Nadol'nik L.I. Stress and thyroid gland / L.I. Nadol'nik // Biomedical Chemistry. – 2010. – № 4. – P. 443–456.

6. Pat. 2356059 Russian Federation, Int. Cl. G01N 33/78. Method of prognosis of clinic course of neurotic disorders [Tekst] / Ivanova S.A., Gutkevich E.V., Semke V.Ja., Vjalova N.M., Rjadovaja L.A., Epanchinceva E.M., Perchatkina O.Je. Proprietor: State institution Scientific Research Institute of Mental Health of the Tomsk Scientific Center of the Siberian Branch of the Russian Academy of Medical Sciences (GU NII PZ TNTs SO RAMN). – № 2007142885/15; application: 19.11.2007; publication: 20.05.2009, Bull. № 14. – 9 p.

7. Pat. 2421727 Russian Federation, Int. Cl. G01N 33/48. Method for prediction of chronic course of neurotic disorders [Tekst] / Nikitina V.B., Vetlugina T.P., Lebedeva V.F., Mal'ceva S.N. Proprietor: Institution of the Russian Academy Medical Sciences Research Institute of Mental health of the Siberian branch of RAMS. – № 2009143442/14; application: 24.11.2009; publication: 20.06.2011, Bull. № 17. – 10 p.

8. Pat. 2427841 Russian Federation, Int. Cl. G01N 33/53. A method for early diagnosis of the course and outcome of neurotic, stress-related, somatoform and neurosis-like disorders / Polozhij B.S., Vernekina N.S. Proprietor: Federal State Institution “State Scientific Center for Social and Forensic Psychiatry named after V.P. Serbsky” (FGU “GNTSSSP Roszdrav”). – № 2009128933/15; application: 28.07.2009; publication: 27.08.2011, Bull. № 24. – 15 p.

9. Pat. 2613111 Russian Federation, Int. Cl. G01N 33/74. Method of predicting course of neurotic stress-associated disorders [Tekst] / Nikitina V.B., Vetlugina T.P., Rudnickij V.A., Perchatkina O.Je., Lebedeva V.F., Bohan N.A. Proprietor: Federal State Budget Scientific Institution “Research Institute of Mental Health”. – № 2015149164; application: 16.11.2015; publication: 15.03.2017, Bull. № 8. – 10 p.

10. Sarsembaev K.T. Biological and social correlates of favorable and unfavorable course of neuroses / K.T. Sarsembaev // S.S. Korsakov Journal of Neurology and Psychiatry. – 2003. – № 5. – Р. 66–70.

11. Jakovleva A.L. Correlation of social adaptation and severity of current depression in patients with comorbid affective and personality disorders / A.L. Jakovleva, G.G. Simutkin // Siberian Herald of Psychiatry and Addiction Psychiatry. – 2016. – № 1. – Р. 15–18.

12. Stein E.J. Chronic mild stress induces wide-spread decreases in thyroid hormone a1 receptor mRNA levels in brain-Reversal by imipramine / E.J. Stein, N.G. da Silveira Filho, D.C. Machado et al. // Psychoneuroendocrinol. – 2009. – Vol. 34. – № 2. – P. 281–286. DOI: 10.1016/j.psyneuen.2008.09.005.

13. Sun Q. Effects of forced swimming stress on thyroid function, pituitary thyroid-stimulating hormone and hypothalamus thyrotropin releasing hormone expression in adrenalectomy Wistar rats / Q. Sun, A. Liu, Y. Ma et al. // Exp. Ther. Med. – 2016. – Vol. 12. – № 5. – Р. 3167–3174. DOI: 10.3892/etm.2016.3790.

14. Erickson K. Glucocorticoid regulation of diverse cognitive functions in normal and pathological emotional states / K. Erickson, W. Drevets, J. Schulkin // Neurosci. Biobehav. Rev. – 2003. – Vol 27. – № 3. – P. 233–246. DOI: 10.1016/s0149-7634(03)00033-2.

15. La\10.3109/10253890.2015.1067678.

16. Wichers M.C. The role of indoleamine 2, 3-dioxygenase (IDO) in the pathophysiology of interferon-alpha-induced depression / M.C. Wichers, M. Maes // J. Psychiatry Neurosci. – 2004. – Vol. 29. – № 4. – Р. 11–17.


Review

For citations:


Nikitina V.B., Perchatkina O.E., Axenov M.M., Kostin A.K. Possibilities of prediction of neurotic, stress-related disorders course in terms of hormonal parameters. Yakut Medical Journal. 2019;(4):51-54. https://doi.org/10.25789/YMJ.2019.68.13

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