Biodegradable vascular patches: a comparative description of physicomechanical and hemocompatible properties
L. V. Antonova,
A. V. Mironov,
V. N. Silnikov,
T. V. Glushkova,
E. O. Krivkina,
T. N. Akentieva,
M. Yu. Khanova,
V. V. Sevostyanova,
J. A. Kudryavtseva,
L. S. Barbarash https://doi.org/10.25789/YMJ.2019.68.08
Abstract
We manufactured electrospun 1.5 mm vascular patches using polycaprolactone and polyhydroxybutirate/valerate, which were modified by different linear or cyclic RGD peptides (RGDK, AhRGD и c[RGDFK]) and 1,6- hexamethylenediamine or 4,7,10-trioxa-1,13-tridecanediamine. The physicomechanical and hemocompatible properties of the developed structures were studied. Human a.mammaria and xenopericardial flap “KemPeriplas-Neo”, widely used in the clinic for carotid endarterectomy, were used as comparison groups. It was revealed that PHBV / PCL polymer patches with and without RGD caused significantly less erythrocyte hemolysis and platelet aggregation than the xenopericardial flap “KemPeriplas-Neo”, which may indicate a high biocompatibility of polymers and modifying agents used to make vascular patches.
Keywords
Supporting agencies: This study was supported by the Complex Program of Basic Research under the Siberian Branch of the Russian Academy of Sciences within the Basic Research Topic of Research Institute for Complex Issues of Cardiovascular Diseases № 0546-2015-0011 “Pathogenetic basis for the development of cardiovascular implants from biocompatible materials using patient-oriented approach, mathematical modeling, tissue engineering, and genomic predictors”.
About the Authors
L. V. Antonova
Medical Sciences Research Institute for Complex Issues of Cardiovascular Diseases
Russian Federation
Russian Federation
Antonova Larisa Valerevn – Doctor
Kemerovo
Head of Cell Technology Laboratory
650056, Kemerovo, Blvd. Stroitelei 39-45, Mob. 8-905-906-04-51
A. V. Mironov
Research Institute for Complex Issues of Cardiovascular Diseases
Russian Federation
Russian Federation
Mironov Andrey Vladimirovich – Junior Researcher, Laboratory of Cell Technology
650044, Kemerovo, Str. Syvorova 18-2, Mob. 8-923-625-90-30
V. N. Silnikov
Chemical Sciences Institute of Chemical Biology and Fundamental Medicine of the Siberian Branch of the Russian Academy of Sciences
Russian Federation
Russian Federation
Silnikov Vladimir Nikolaevich – Doctor
Head of Organic Synthesis Laboratory
630090, Novosibirsk, Ave. Akademika Koptyuga 5-2, Сот. 8-905-930-81-85
T. V. Glushkova
Biological Sciences Research Institute for Complex Issues of Cardiovascular Diseases
Russian Federation
Russian Federation
Glushkova Tatyana Vladimirovna – PhD
Researcher at the Laboratory of New Biomaterials
650061, Kemerovo, Ave. Shahterov, 62B-2, Mob. 8-923-606-97-18
E. O. Krivkina
Research Institute for Complex Issues of Cardiovascular Diseases
Russian Federation
Russian Federation
Krivkina Evgeniya Olegovna – Junior Researcher, Laboratory of Cell Technology
650024, Kemerovo, Str. Radischeva 15-7, Mob. 8-908-946-66-39
T. N. Akentieva
Research Institute for Complex Issues of Cardiovascular Diseases
Russian Federation
Russian Federation
Akentieva Tatyana Nikolaevna – Junior Researcher, Laboratory of New Biomaterials
650061, Kemerovo, Str. Serebryannyi bor 7-50, Mob. 8-923-606-07-07
M. Yu. Khanova
Research Institute for Complex Issues of Cardiovascular Diseases
Russian Federation
Russian Federation
Khanova Maryam Yurisovna – Junior Researcher, Laboratory of Cell Technology
650065, Kemerovo, Ave, Oktyabrskii 80 G – 30, Mob. 8-904-374-36-61
V. V. Sevostyanova
Research Institute for Complex Issues of Cardiovascular Diseases
Russian Federation
Russian Federation
Sevostyanova Victoria Vladimirovna – PhD of Medical Sciences
Kemerovo Researcher, Laboratory of Cell Technology
650061, Kemerovo, Str. Serebryannyi bor, 1-27, Mob. 8-906-935-60-76
J. A. Kudryavtseva
Research Institute for Complex Issues of Cardiovascular Diseases
Russian Federation
Russian Federation
Kudryavtseva Julia Alexandrovna – Doctor of Medical Sciences
Kemerovo Head of the Department of Experimental and Clinical Cardiology
650071, Kemerovo, Str. Okryzhnaya 30 – 246, Mob. 8-905-902-61-84
L. S. Barbarash
Research Institute for Complex Issues of Cardiovascular Diseases;
Research Institute for Complex Issues of Cardiovascular Diseases
Russian Federation
Russian Federation
Barbarash Leonid Semenovich – Doctor of Medical Sciences, Professor, Academician Russian Academy of Sciences
Chief Researcher
650065, Kemerovo, Blvd. Stroitelei 28/1 – 23, Tel. 8(3842) 64-33-08
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Review
For citations:
Antonova L.V., Mironov A.V., Silnikov V.N., Glushkova T.V., Krivkina E.O., Akentieva T.N., Khanova M.Yu., Sevostyanova V.V., Kudryavtseva J.A., Barbarash L.S. Biodegradable vascular patches: a comparative description of physicomechanical and hemocompatible properties. Yakut Medical Journal. 2019;(4):35-39. https://doi.org/10.25789/YMJ.2019.68.08
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