Endogenous retrovirus HERV - E λ 4-1 influence on immune cells functional activity in multiple sclerosis patients
https://doi.org/10.25789/YMJ.2019.68.07
Abstract
A comparative study of the blood immune cells functional activity in multiple sclerosis (MS) patients associated with the human endogenous retrovirus HERV - E λ 4-1 activation, as well as the immunomodulating properties of the homologous to a conservative region of hydrophobic transmembrane protein p15E 17 - amino acid synthetic oligopeptide was held.
We found that multiple sclerosis patients with activated retrovirus HERV - E λ 4-1 are characterized by a higher blood immune cells functional activity, compared with healthy donors, as well as in MS patients, in whose blood mononuclear cells the expression of this retrovirus was not detected. Synthetic 17 - amino acid oligopeptide, homologous to the conservative region of the hydrophobic transmembrane protein p15E of the HERV retrovirus - E λ 4-1, increases the functional activity of blood mononuclear cells of MS patients, as well as the immune system central and peripheral organs cells and blood mononuclear cells of experimental animals in vivo. This oligopeptide’s effect was not genetically restricted.
About the Authors
I. A. Goldina
Federal State Budgetary Scientific Research Institute of Fundamental and Clinical Immunology
Russian Federation
Russian Federation
Goldina Irina Alexandrovna1, Researcher of Neuroimmunology Laboratory
14 Yadrincevskaya str., Novosibirsk, +7 905 936 88 80
E. V. Markova
Federal State Budgetary Scientific Research Institute of Fundamental and Clinical Immunology;
Federal State Budgetary Educational Institution of Higher Education “Novosibirsk State Pedagogical University»
Russian Federation
Russian Federation
Markova Evgeniya Valerievna, , DM, Professor, Head of Neuroimmunology Laboratory, Chief Researcher;
Professor
28 Viluyskaya str., Novosibirsk, +7 903 934 67 86
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For citations:
Goldina I.A., Markova E.V. Endogenous retrovirus HERV - E λ 4-1 influence on immune cells functional activity in multiple sclerosis patients. Yakut Medical Journal. 2019;(4):32-35. https://doi.org/10.25789/YMJ.2019.68.07
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