Molecular genetic studies as an auxiliary method for determining risk factors in the clinical examination of the adult population

Abstract

Indicators of morbidity of adult population according to out-patient office of Hospital of the Yakut Science Center of Complex Medical Problems (Yakutsk) during 2015-2017 are presented in article. The characteristic of dynamics and structure of cases of the general and primary incidence is given. Decrease in level of the general incidence for all analyzed period is established. In structure of the general incidence of adult population the prevalence of diseases of respiratory organs and the blood circulatory system is revealed. The analysis of dynamics of indicators of primary incidence has shown the stable growth of her level with prevalence a case of diseases of respiratory organs. The obtained data on the dynamics and distribution patterns of diseases have served as the basis for selecting the directions of molecular genetic research, the search for associations of genetic markers of the system of cytokines responsible for the development and maintenance in the body of chronic systemic inflammation, the genes B2 - adrenoreceptor and genes of cold receptors involved in the hereditary predisposition to hyperreactivity of the respiratory and the cardiovascular system in response to the effects of low temperatures.