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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">ymj</journal-id><journal-title-group><journal-title xml:lang="ru">Якутский медицинский журнал</journal-title><trans-title-group xml:lang="en"><trans-title>Yakut Medical Journal</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1813-1905</issn><issn pub-type="epub">2312-1017</issn><publisher><publisher-name>ЯНЦ КМП</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.25789/YMJ.2018.64.23</article-id><article-id custom-type="elpub" pub-id-type="custom">ymj-1154</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>АКТУАЛЬНАЯ ТЕМА</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ACTUAL TOPIC</subject></subj-group></article-categories><title-group><article-title>Молекулярно-генетические исследования как вспомогательный метод определения факторов риска при диспансеризации взрослого населения</article-title><trans-title-group xml:lang="en"><trans-title>Molecular genetic studies as an auxiliary method for determining risk factors in the clinical examination of the adult population</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сизых</surname><given-names>Е. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Sizykh</surname><given-names>E. Yu.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Сизых Елена Юрьевна – м.н.с., зав. поликлиникой Больницы </p></bio><bio xml:lang="en"><p>Sizykh Elena Yuryevna - junior researcher associate of laboratory of population genetics of department of molecular genetics</p></bio><email xlink:type="simple">sizyx@inbox.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Соловьева</surname><given-names>Н. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Solovyova</surname><given-names>N. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Соловьева Наталья Алексеевна – к.м.н., с.н.с. </p></bio><bio xml:lang="en"><p>Solovyova Natalya Alekseevna - candidate of medical sciences, senior research associate of laboratory of population genetics of department of molecular genetics</p><p>677010, Yakutsk, Sergelyakhskoye Highway 4 </p><p> 8-924-171-34- 89 </p></bio><email xlink:type="simple">sonata608@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Варламова</surname><given-names>М. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Varlamova</surname><given-names>M. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Варламова Марина Алексеевна – н.с. </p></bio><bio xml:lang="en"><p>Varlamova Marina Alekseevna - research associate of laboratory of hereditary pathology of department of molecular genetics</p></bio><email xlink:type="simple">varlamova.m@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Дьяконова</surname><given-names>А. Т.</given-names></name><name name-style="western" xml:lang="en"><surname>Dyakonova</surname><given-names>A. T.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Дьяконова Александра Тимофеевна – м.н.с. </p></bio><email xlink:type="simple">dyakonovaa@bk.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Куртанов</surname><given-names>Х. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Kurtanov</surname><given-names>Kh. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Куртанов Харитон Алексеевич – к.м.н., гл.н.с.-руковод. отдела </p></bio><bio xml:lang="en"><p>Kurtanov Khariton Alekseyevich - candidate of medical sciences, the chief researcher – head of department of molecular genetics</p></bio><email xlink:type="simple">hariton_kurtanov@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Павлова</surname><given-names>Н. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Pavlova</surname><given-names>N. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Павлова Надежда Ивановна – к.б.н., в.н.с.- руковод. лаб. </p></bio><bio xml:lang="en"><p>Pavlova Nadezhda Ivanovna - сandidate of biology sciences, the leading researcher - the head of laboratory of hereditary pathology of department of molecular genetics</p></bio><email xlink:type="simple">solnishko_84@inbox.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ЯНЦ КМП</institution><country>Россия</country></aff><aff xml:lang="en"><institution>FGBNU “The Yakut science center of complex medical problems”</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2018</year></pub-date><pub-date pub-type="epub"><day>29</day><month>08</month><year>2025</year></pub-date><volume>0</volume><issue>4</issue><fpage>75</fpage><lpage>77</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Сизых Е.Ю., Соловьева Н.А., Варламова М.А., Дьяконова А.Т., Куртанов Х.А., Павлова Н.И., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Сизых Е.Ю., Соловьева Н.А., Варламова М.А., Дьяконова А.Т., Куртанов Х.А., Павлова Н.И.</copyright-holder><copyright-holder xml:lang="en">Sizykh E.Y., Solovyova N.A., Varlamova M.A., Dyakonova A.T., Kurtanov K.A., Pavlova N.I.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://ymj.elpub.ru/jour/article/view/1154">https://ymj.elpub.ru/jour/article/view/1154</self-uri><abstract><p>В статье представлены показатели заболеваемости взрослого населения по данным амбулаторного отделения Больницы ЯНЦ КМП (Якутия) за период 2015-2017 гг. Дана характеристика динамики и структуры случаев общей и первичной заболеваемости. Установлено снижение уровня общей заболеваемости за весь анализируемый период. В структуре общей заболеваемости взрослого населения выявлено преобладание заболеваний органов дыхания и системы кровообращения. Анализ динамики показателей первичной заболеваемости продемонстрировал стабильный рост ее уровня с преобладанием случаев заболеваний органов дыхания и мочеполовой системы.</p></abstract><trans-abstract xml:lang="en"><p>Indicators of morbidity of adult population according to out-patient office of Hospital of the Yakut Science Center of Complex Medical Problems (Yakutsk) during 2015-2017 are presented in article. The characteristic of dynamics and structure of cases of the general and primary incidence is given. Decrease in level of the general incidence for all analyzed period is established. In structure of the general incidence of adult population the prevalence of diseases of respiratory organs and the blood circulatory system is revealed. The analysis of dynamics of indicators of primary incidence has shown the stable growth of her level with prevalence a case of diseases of respiratory organs. The obtained data on the dynamics and distribution patterns of diseases have served as the basis for selecting the directions of molecular genetic research, the search for associations of genetic markers of the system of cytokines responsible for the development and maintenance in the body of chronic systemic inflammation, the genes B2 - adrenoreceptor and genes of cold receptors involved in the hereditary predisposition to hyperreactivity of the respiratory and the cardiovascular system in response to the effects of low temperatures.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>диспансеризация</kwd><kwd>заболеваемость общая и первичная</kwd><kwd>структура и динамика заболеваемости</kwd></kwd-group><kwd-group xml:lang="en"><kwd>clinical examination</kwd><kwd>morbidity general and primary</kwd><kwd>structure and dynamics of morbidity</kwd><kwd>genes of cytokines</kwd><kwd>adrenoreceptor genes</kwd><kwd>cold receptor genes</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Наглядная медицинская статистика / под редакцией В.П. 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