Treatment of the Epstein-Barr virus chronic infection in children

Abstract

Article is devoted to an actual problem of modern medicine – Epstein Barr virus infection (EBV). We examined a group of children aged from 5 to 10 years with low-grade fever of unknown origin and manifestations of oral herpes with positive ELISA (IgG-VCA in high titers, IgG-EBNA, IgGEA) and PCR for EBV. The children underwent a two-stage treatment: inosinepranobex at a dose of 5 mg/kg per day for 10 days, likopid 1 mg 1 time a day for 10 days. After treatment for 30 days ELISA and PCR for virus infection Epstein Barr were re-conducted. It was revealed that in 90% of children there were not detected positive IgG-VCA, IgG-EA; positive IgG-EBNA was observed in 20% of children. Positive PCR on EBV were detected in 20% of examined children. There was also an increase of reduced levels of СD3+, CD4+, CD16+.