Replicative analysis of hereditary thrombophilia factors in the development of preeclampsia in the Yakut population
https://doi.org/10.25789/YMJ.2019.68.03
Abstract
We conducted a replicative associations analysis of the single-nucleotide polymorphisms of 4 most significant genes of hereditary thrombophilia with the development of preeclampsia (PE) in the Yakut population: rs1801133 (C677T) in the MTHFR gene, rs1799963 (G20210A) in the F2, rs6025 (G999A) in the F5 gene and rs1799889 (-675 4G/5G) in the SERPINE1 gene. The results of this study indicate a statistically significant association of 4G allele of polymorphic variant rs1799889 (-675 4G/5G) in the SERPINE1 gene in formation of a hereditary predisposition to the development of this pregnancy complication in Yakuts, both in the general group of patients and in the subgroup of patients with severe PE.
Supporting agencies: This work was supported by the Russian Foundation for Basic Research (Grant No. 18-44-700007).
About the Authors
V. N. Serebrova
Research Institute of Medical Genetics, Tomsk NRMC
Russian Federation
Russian Federation
Serebrova Victoria Nicolaevna – Candidate of Medical Sciences, Junior researcher
Nab. Ushaiki, 10, Tomsk, 634050
E. A. Trifonova
Research Institute of Medical Genetics, Tomsk NRMC
Russian Federation
Russian Federation
Trifonova Ekaterina Aleksandrovna – Candidate of Medical Sciences, Researcher
Nab. Ushaiki, 10, Tomsk, 634050
K. K. Pavlova
State Autonomous Institution of the Republic of Sakha (Yakutia) “Republican Hospital No. 1-National Center of Medicine”
Russian Federation
Russian Federation
Pavlova Kunna Konstantinovna – Candidate of Medical Sciences, doctor - laboratory geneticist
Sergelyakhskoye hwy, 4, Yakutsk, 677010
A. Yu. Vorozhishcheva
The government owned autonomous health-care institution of Kemerovo Oblast «Novokuznetsk municipal clinical hospital № 1»
Russian Federation
Russian Federation
Vorozhishcheva Anna Yuryevna – Candidate of Medical Sciences, Head of Clinical Laboratory
Bardina Ave., 28, Novokuznetsk, 654057
Kh. A. Kurtanov
Yakut Science Centre of complex medical problems
Russian Federation
Russian Federation
Kurtanov Khariton Alekseevich, Candidate of Medical Sciences, Chief Researcher, Head of Molecular Genetics Department
Sergelyakhskoye hwy, 4, Yakutsk, 677000
N. I. Pavlova
Yakut Science Centre of complex medical problems
Russian Federation
Russian Federation
Pavlova Nadezhda Ivanovna - Candidate of biological Sciences, temporary acting chief scientific officer - head of the laboratory of heritable pathology
Sergelyakhskoye hwy, 4, Yakutsk, 677000
V. A. Stepanov
Tomsk National Research Medical Center of the Russian Academy of Sciences (Tomsk NRMC);
Institute of Medical Genetics, Tomsk NRMC
Russian Federation
Russian Federation
Stepanov Vadim Anatolevich – Corresponding Member of the Russian Academy of Sciences, Doctor of Biology Sciences, Professor. Acting Director;
Head of the Laboratory of Evolutionary genetics
Nab. Ushaiki, 10, Tomsk, 634050
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Review
For citations:
Serebrova V.N., Trifonova E.A., Pavlova K.K., Vorozhishcheva A.Yu., Kurtanov Kh.A., Pavlova N.I., Stepanov V.A. Replicative analysis of hereditary thrombophilia factors in the development of preeclampsia in the Yakut population. Yakut Medical Journal. 2019;(4):15-19. https://doi.org/10.25789/YMJ.2019.68.03
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