Stress-protective and antioxidant effect of the tincture Сimicifuga dahurica (Turcz) Maxim
Abstract
The stress-protective and antioxidant effects of Cimicifuga dahurica (Turcz) Maxim tincture were estimated in the experiments on white Wistar rats. The stress-induced condition was simulated by immobilization of the animals for 18 hours. There was estimated the evidence of the Selye’s triad (hypertrophy of adrenal glands, involution of thymus and spleen, and gastric mucous membrane ulceration, with determination of the Pauls index), the content of malonic dialdehyde and activity of catalase in the blood serum and superoxide dismutase in erythrocytes and the content of the reduced glutathione in the blood. It has been revealed that the C. dahurica tincture has a marked stress-protective effect, preventing hypertrophy of the adrenal glands, involution of thymus and spleen, development of ulcerative lesions of the gastric mucosa. The C. dahurica tincture inhibits lipid peroxidation and activates the antioxidant system of the body in stress-induced conditions.
About the Authors
Ya. G. Razuvaeva
Институт общей и экспериментальной биологии СО РАН
Russian Federation
Russian Federation
A. A. Toropova
Институт общей и экспериментальной биологии СО РАН
Russian Federation
Russian Federation
D. E. Garmaev
Институт общей и экспериментальной биологии СО РАН
Russian Federation
Russian Federation
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Review
For citations:
Razuvaeva Ya.G., Toropova A.A., Garmaev D.E. Stress-protective and antioxidant effect of the tincture Сimicifuga dahurica (Turcz) Maxim. Yakut Medical Journal. 2017;(4):57-59.
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