Experimental phytocorrection of acute D-galactosamine hepatitis in white rats
https://doi.org/10.25789/YMJ.2018.64.09
Abstract
The aim of our research was in defining hepatoprotective properties of new complex plant supplement on a rat model of D-galactosamine hepatitis. The new complex drug supplement is a dry extract consisting of Hypecoum erectus L., Hedysarum dauricum, Glycyrhhiza uralensis Fisch., Calendula officinalis and Scutellaria baicalensis. Intensity of the main pathogenetic syndromes was evaluated by biochemical tests, lipid peroxidation grade and morphological research. The use for the complex extract resulted in correction of functional state of the liver, inhibition of cytolysis and cholestasis, delay of LPO and enhancing synthetic function of liver manifested in albumin and fibrinogen increase.
About the Authors
E. A. Ubeeva
Buryat State University
Russian Federation
Russian Federation
Elena A. Ubeeva, research assistant
Y. G. Razuvayeva
SB RAS
Russian Federation
Russian Federation
Yanina G. Razuvaeva, doctor of biological sciences, senior scientific researcher of laboratory of safety of biological active substances of the Institutes of General and Experimental Biology
D. N. Olennikov
SB RAS
Russian Federation
Russian Federation
Daniel N. Olennikov, doctor of biological sciences, senior scientific researcher of laboratory of the Institutes of General and Experimental Biology
I. P. Ubeeva
FGBOU VO Buryat State University; professor chair of clinical pharmacology of Irkutsk state Institute for postgraduate education medical
Belarus
Belarus
Iraida P. Ubeeva, doctor of medical sciences, professor, the manager chair of the infection diseases
S. M. Nicolaev
SB RAS; FGBOU VO Buryat State University
Russian Federation
Russian Federation
Sergey M. Nicolaev, professor, doctor of medical sciences, scientific researcher of laboratory of safety of biological active substances of the Institutes of General and Experimental Biology; professor chair of clinical pharmacology of Irkutsk state Institute for postgraduate education medical, professor chair of pharmacology
L. D. Dymsheeva
FGBOU VO Buryat State University
Belarus
Belarus
Larisa D. Dymsheeva – PhD, docent
References
1. Atlas of medicinal plants of Russia / V.A. Bykov, T.A. Sokolskaya, L.N. Zayko [et al.]. – M.: VILAR, 2006. – P. 122-124.
2. Lesiovskaya E.E. Evidence-based medicine / E.E. Lesiovskaya. – M.: Medicina. – P. I– 214 p., P.II – 684 p.
3. Nikolaev S.М. Phytopharmacotherapy and phytopharmacoprevention of diseases / S.М. Nikolaev. – Ulan-Ude. – 2012. – 286 p.
4. Nikonov G.K. Basics of modern herbal medicine / G.K. Nikonov, B.М. Manuilov. – M.: Medicina, 2005. – 520 p.
5. Manual on experimental (preclinical) study of new pharmacological substances / Ed. by R. Y. Khabriev. – М., 2012. – 832 p.
6. Sergienko V.I. Mathematical statistics in clinical studies / V.I. Sergienko, I.B. Bondarenko, I.I. Gaydyshev. – M.: Medicine, 2001. – 256 p.
7. Physiological, biochemical and biometric standards of experimental animals: handbook / Abrashova T.V. [et al.] / Ed. Makarov V.G., Makarova M.N. – SPb.: Lema, 2013. – 116 p.
8. Yushchuk N.D. Infectious diseases: national guideline / N.D. Yushchuk, Yu. Ya.Vengerov. – M.: GEOTAR-Media, 2010. – 1056 p.
9. Yushchuk N.D. Treatment of chronic hepatitis C in Russia: current opportunities and immediate prospects / N.D. Yuschuk, E.A. Klimova // Infectious diseases: news, opinions, training. - M., 2017. - №2. - P. 86–95. doi: 10.24411/2305-3496-2017-00039
10. Sherlock Sh. Diseases of the Liver & Biliary System / Sh. Sherlock, J. Dooley. - 11th edition. - London, Blackwell, 2002. - 864 р.
Review
For citations:
Ubeeva E.A., Razuvayeva Y.G., Olennikov D.N., Ubeeva I.P., Nicolaev S.M., Dymsheeva L.D. Experimental phytocorrection of acute D-galactosamine hepatitis in white rats. Yakut Medical Journal. 2018;(4):33-36. https://doi.org/10.25789/YMJ.2018.64.09
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